A Human Embryonic Stem Cell Model of Aβ-Dependent Chronic Progressive Neurodegeneration

A Human Embryonic Stem Cell Model of Aβ-Dependent Chronic Progressive Neurodegeneration

We describe the construction and phenotypic analysis of a human embryonic stem cell model of progressive Aβ-dependent neurodegeneration (ND) with potential relevance to Alzheimer’s disease (AD). We modified one allele of the normal APP locus to directly express a secretory form of Aβ40 or Aβ42, enab...

Full description

Bibliographic Details
Main Authors: Teresa Ubina, Martha Magallanes, Saumya Srivastava, Charles D. Warden, Jiing-Kuan Yee, Paul M. Salvaterra
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neuroscience
Subjects:
amyloid-beta
neurodegeneration
stem cells
Alzheimer’s disease
Alzheimer’s model
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01007/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.01007/full

Similar Items