Rapidly progressive immunoglobulin M monoclonal gammopathy presenting with nephrotic syndrome and hepatic failure

We report a 73-year-old male with no relevant past medical history who presented with nephrotic syndrome and jaundice. Subsequent studies revealed immunoglobulinM (IgM) monoclonal gammopathy. Kidney biopsy revealed monoclonal Ig deposition disease and amyloidosis. Bone marrow biopsy demonstrated <...

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Main Author:	Yao-Ko Wen
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2020-01-01
Series:	Saudi Journal of Kidney Diseases and Transplantation
Online Access:	http://www.sjkdt.org/article.asp?issn=1319-2442;year=2020;volume=31;issue=6;spage=1399;epage=1402;aulast=Wen

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spelling	doaj-2ec23e6c83b64ab096f1a0f3842113bb2021-02-03T07:09:11ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422020-01-013161399140210.4103/1319-2442.308354Rapidly progressive immunoglobulin M monoclonal gammopathy presenting with nephrotic syndrome and hepatic failureYao-Ko WenWe report a 73-year-old male with no relevant past medical history who presented with nephrotic syndrome and jaundice. Subsequent studies revealed immunoglobulinM (IgM) monoclonal gammopathy. Kidney biopsy revealed monoclonal Ig deposition disease and amyloidosis. Bone marrow biopsy demonstrated <10% infiltration by lymphoplasmacytic cells. However, rapidly progressive hypergammaglobulinemia of IgM and hyperbilirubinemia were noted. Despite aggressive treatment, the patient developed acute kidney injury and complications of hepatic failure. He eventually died of pneumonia, just two months after diagnosis.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2020;volume=31;issue=6;spage=1399;epage=1402;aulast=Wen
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yao-Ko Wen
spellingShingle	Yao-Ko Wen Rapidly progressive immunoglobulin M monoclonal gammopathy presenting with nephrotic syndrome and hepatic failure Saudi Journal of Kidney Diseases and Transplantation
author_facet	Yao-Ko Wen
author_sort	Yao-Ko Wen
title	Rapidly progressive immunoglobulin M monoclonal gammopathy presenting with nephrotic syndrome and hepatic failure
title_short	Rapidly progressive immunoglobulin M monoclonal gammopathy presenting with nephrotic syndrome and hepatic failure
title_full	Rapidly progressive immunoglobulin M monoclonal gammopathy presenting with nephrotic syndrome and hepatic failure
title_fullStr	Rapidly progressive immunoglobulin M monoclonal gammopathy presenting with nephrotic syndrome and hepatic failure
title_full_unstemmed	Rapidly progressive immunoglobulin M monoclonal gammopathy presenting with nephrotic syndrome and hepatic failure
title_sort	rapidly progressive immunoglobulin m monoclonal gammopathy presenting with nephrotic syndrome and hepatic failure
publisher	Wolters Kluwer Medknow Publications
series	Saudi Journal of Kidney Diseases and Transplantation
issn	1319-2442
publishDate	2020-01-01
description	We report a 73-year-old male with no relevant past medical history who presented with nephrotic syndrome and jaundice. Subsequent studies revealed immunoglobulinM (IgM) monoclonal gammopathy. Kidney biopsy revealed monoclonal Ig deposition disease and amyloidosis. Bone marrow biopsy demonstrated <10% infiltration by lymphoplasmacytic cells. However, rapidly progressive hypergammaglobulinemia of IgM and hyperbilirubinemia were noted. Despite aggressive treatment, the patient developed acute kidney injury and complications of hepatic failure. He eventually died of pneumonia, just two months after diagnosis.
url	http://www.sjkdt.org/article.asp?issn=1319-2442;year=2020;volume=31;issue=6;spage=1399;epage=1402;aulast=Wen
work_keys_str_mv	AT yaokowen rapidlyprogressiveimmunoglobulinmmonoclonalgammopathypresentingwithnephroticsyndromeandhepaticfailure
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Rapidly progressive immunoglobulin M monoclonal gammopathy presenting with nephrotic syndrome and hepatic failure

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