Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases

Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases

An epidemiological association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) is well-established, but a genetic link is unclear. Here, the authors investigate the shared genetic architecture between MS and IBD to shed light on the biological basis of comorbidity.

Bibliographic Details
Main Authors: Yuanhao Yang, Hannah Musco, Steve Simpson-Yap, Zhihong Zhu, Ying Wang, Xin Lin, Jiawei Zhang, Bruce Taylor, Jacob Gratten, Yuan Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25768-0
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spelling doaj-2ec0b36ae4d245beadcad12099f9f93a2021-09-26T11:44:43ZengNature Publishing GroupNature Communications2041-17232021-09-0112111210.1038/s41467-021-25768-0Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseasesYuanhao Yang0Hannah Musco1Steve Simpson-Yap2Zhihong Zhu3Ying Wang4Xin Lin5Jiawei Zhang6Bruce Taylor7Jacob Gratten8Yuan Zhou9Mater Research, Translational Research InstituteMater Research, Translational Research InstituteMenzies Institute for Medical Research, University of TasmaniaInstitute for Molecular Bioscience, The University of QueenslandMater Research, Translational Research InstituteMenzies Institute for Medical Research, University of TasmaniaDepartment of General Surgery, the First Affiliated Hospital of Anhui Medical UniversityMenzies Institute for Medical Research, University of TasmaniaMater Research, Translational Research InstituteMenzies Institute for Medical Research, University of TasmaniaAn epidemiological association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) is well-established, but a genetic link is unclear. Here, the authors investigate the shared genetic architecture between MS and IBD to shed light on the biological basis of comorbidity.https://doi.org/10.1038/s41467-021-25768-0
collection DOAJ
language English
format Article
sources DOAJ
author Yuanhao Yang
Hannah Musco
Steve Simpson-Yap
Zhihong Zhu
Ying Wang
Xin Lin
Jiawei Zhang
Bruce Taylor
Jacob Gratten
Yuan Zhou
spellingShingle Yuanhao Yang
Hannah Musco
Steve Simpson-Yap
Zhihong Zhu
Ying Wang
Xin Lin
Jiawei Zhang
Bruce Taylor
Jacob Gratten
Yuan Zhou
Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
Nature Communications
author_facet Yuanhao Yang
Hannah Musco
Steve Simpson-Yap
Zhihong Zhu
Ying Wang
Xin Lin
Jiawei Zhang
Bruce Taylor
Jacob Gratten
Yuan Zhou
author_sort Yuanhao Yang
title Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
title_short Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
title_full Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
title_fullStr Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
title_full_unstemmed Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
title_sort investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-09-01
description An epidemiological association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) is well-established, but a genetic link is unclear. Here, the authors investigate the shared genetic architecture between MS and IBD to shed light on the biological basis of comorbidity.
url https://doi.org/10.1038/s41467-021-25768-0
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AT hannahmusco investigatingthesharedgeneticarchitecturebetweenmultiplesclerosisandinflammatoryboweldiseases
AT stevesimpsonyap investigatingthesharedgeneticarchitecturebetweenmultiplesclerosisandinflammatoryboweldiseases
AT zhihongzhu investigatingthesharedgeneticarchitecturebetweenmultiplesclerosisandinflammatoryboweldiseases
AT yingwang investigatingthesharedgeneticarchitecturebetweenmultiplesclerosisandinflammatoryboweldiseases
AT xinlin investigatingthesharedgeneticarchitecturebetweenmultiplesclerosisandinflammatoryboweldiseases
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AT brucetaylor investigatingthesharedgeneticarchitecturebetweenmultiplesclerosisandinflammatoryboweldiseases
AT jacobgratten investigatingthesharedgeneticarchitecturebetweenmultiplesclerosisandinflammatoryboweldiseases
AT yuanzhou investigatingthesharedgeneticarchitecturebetweenmultiplesclerosisandinflammatoryboweldiseases
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