PRMT5 Promotes EMT Through Regulating Akt Activity in Human Lung Cancer

PRMT5 Promotes EMT Through Regulating Akt Activity in Human Lung Cancer

The type II protein arginine methyltransferase 5 (PRMT5) has been engaged in various human cancer development and progression types. Nevertheless, few studies uncover the biological functions of PRMT5 in the epithelial-mesenchymal transition (EMT) of human lung cancer cells, and the associated molec...

Full description

Bibliographic Details
Main Authors:	Jianhao Huang, Yonghua Zheng, Xiao Zheng, Bao Qian, Qi Yin, Jingjing Lu, Han Lei
Format:	Article
Language:	English
Published:	SAGE Publishing 2021-04-01
Series:	Cell Transplantation
Online Access:	https://doi.org/10.1177/09636897211001772

Similar Items

PRMT5 Promotes Human Lung Cancer Cell Apoptosis via Akt/Gsk3β Signaling Induced by Resveratrol
by: Yong Li, et al.
Published: (2019-12-01)

PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis
by: Shasha Yin, et al.
Published: (2021-06-01)

TASP1 Promotes Proliferation and Migration in Gastric Cancer via EMT and AKT/P-AKT Pathway
by: Xue-Mei Wan, et al.
Published: (2021-01-01)

Regulation of a PRMT5/NF-κB Axis by Phosphorylation of PRMT5 at Serine 15 in Colorectal Cancer
by: Antja-Voy Hartley, et al.
Published: (2020-05-01)

The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells
by: Mingyue Li, et al.
Published: (2019-02-01)

PRMT5 determines the pattern of polyploidization and prevents liver from cirrhosis and carcinogenesis
by: Bao, S., et al.
Published: (2022)

Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity.
by: Aurélie Quillien, et al.
Published: (2021-06-01)

The methyltransferases PRMT4/CARM1 and PRMT5 control differentially myogenesis in zebrafish.
by: Julie Batut, et al.
Published: (2011-01-01)

FGFR3 promotes the growth and malignancy of melanoma by influencing EMT and the phosphorylation of ERK, AKT, and EGFR
by: Lei Li, et al.
Published: (2019-10-01)

PRMT5 function and targeting in cancer
by: Hyungsoo Kim, et al.
Published: (2020-07-01)

NECTIN4 promotes papillary thyroid cancer cell proliferation, migration, and invasion and triggers EMT by activating AKT
by: Hao RT, et al.
Published: (2019-04-01)

PRMT5 Selective Inhibitor Enhances Therapeutic Efficacy of Cisplatin in Lung Cancer Cells
by: Khuloud Bajbouj, et al.
Published: (2021-06-01)

EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway
by: Cheng Xie, et al.
Published: (2020-01-01)

AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer
by: Xu F, et al.
Published: (2020-03-01)

PRMT5-mediated regulation of developmental myelination
by: Antonella Scaglione, et al.
Published: (2018-07-01)

NECTIN4 Promotes Papillary Thyroid Cancer Cell Proliferation, Migration, and Invasion and Triggers EMT by Activating AKT [Corrigendum]
by: Hao RT, et al.
Published: (2019-11-01)

SPNS2 Downregulation Induces EMT and Promotes Colorectal Cancer Metastasis via Activating AKT Signaling Pathway
by: Lei Lv, et al.
Published: (2021-06-01)

PAK5 Induces EMT and Promotes Cell Migration and Invasion by Activating the PI3K/AKT Pathway in Ovarian Cancer
by: Diyou Li, et al.
Published: (2018-01-01)

PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling
by: Yonghui Dong, et al.
Published: (2020-09-01)

PRMT5 inhibition disrupts splicing and stemness in glioblastoma
by: Patty Sachamitr, et al.
Published: (2021-02-01)

Arginine methylation by PRMT1 and PRMT5 regulates B cell activation, germinal center expansion and differentiation into plasma cells
by: Litzler, Ludivine
Published: (2018)

MFAP5 promotes basal-like breast cancer progression by activating the EMT program
by: Yanmei Wu, et al.
Published: (2019-03-01)

Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii
by: Min Liu, et al.
Published: (2019-05-01)

KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT
by: Yang Gao, et al.
Published: (2020-01-01)

The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation
by: Zhenzhen Yan, et al.
Published: (2021-09-01)

PRMT5 promotes progression of endometrioid adenocarcinoma via ERα and cell cycle signaling pathways
by: Shuyu Mei, et al.
Published: (2021-03-01)

EMT or EMT-promoting transcription factors, where to focus the light?
by: Stéphane eAnsieau, et al.
Published: (2014-12-01)

PRMT5 regulates ovarian follicle development by facilitating Wt1 translation
by: Min Chen, et al.
Published: (2021-08-01)

The mechanisms and cellular significances of PRMT5-induced HURP methylation
by: Yi-Chun Kuo, et al.
Published: (2015)

The Role of the PRMT5–SND1 Axis in Hepatocellular Carcinoma
by: Tanner Wright, et al.
Published: (2021-01-01)

Developmental expression of three prmt genes in Xenopus
by: Cheng-Dong Wang, et al.
Published: (2019-01-01)

PRMT7 contributes to the metastasis phenotype in human non-small-cell lung cancer cells possibly through the interaction with HSPA5 and EEF2
by: Cheng D, et al.
Published: (2018-08-01)

RBFOX3 Regulates the Chemosensitivity of Cancer Cells to 5-Fluorouracil via the PI3K/AKT, EMT and Cytochrome-C/Caspase Pathways
by: Tianze Liu, et al.
Published: (2018-04-01)

Meta-Analysis of EMT Datasets Reveals Different Types of EMT.
by: Lining Liang, et al.
Published: (2016-01-01)

Protein distribution, gene structures and alternative splicing of highly conserved PRMT1 and PRMT8
by: Li-Ching Chuang, et al.
Published: (2014)

AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation
by: Han Tian, et al.
Published: (2020-10-01)

PRMT5 Promotes Aerobic Glycolysis and Invasion of Breast Cancer Cells by Regulating the LXRα/NF-κBp65 Pathway
by: Han X, et al.
Published: (2020-04-01)

PRMT5 is essential for B cell development and germinal center dynamics
by: Ludivine C. Litzler, et al.
Published: (2019-01-01)

PRMT5 Is Required for T Cell Survival and Proliferation by Maintaining Cytokine Signaling
by: Yukinori Tanaka, et al.
Published: (2020-04-01)

KAP1 is a Novel Substrate for the Arginine Methyltransferase PRMT5
by: Roberta di Caprio, et al.
Published: (2015-01-01)