Tautomerase Activity-Lacking of the Macrophage Migration Inhibitory Factor Alleviates the Inflammation and Insulin Tolerance in High Fat Diet-Induced Obese Mice

Tautomerase Activity-Lacking of the Macrophage Migration Inhibitory Factor Alleviates the Inflammation and Insulin Tolerance in High Fat Diet-Induced Obese Mice

Macrophage migration inhibitory factor (MIF) has multiple intrinsic enzymatic activities of the dopachrome/phenylpyruvate tautomerase and thiol protein oxidoreductase, and plays an important role in the development of obesity as a pro-inflammatory cytokine. However, which enzymatic activity of MIF i...

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Bibliographic Details
Main Authors: Yan-Hong Li, Ke Wen, Ling-Ling Zhu, Sheng-Kai Lv, Qing Cao, Qian Li, Libin Deng, Tingtao Chen, Xiaolei Wang, Ke-Yu Deng, Ling-Fang Wang, Hong-Bo Xin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Endocrinology
Subjects:
macrophage migration inhibitory factor
obesity
inflammation
insulin resistance
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00134/full

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