Pichia pastoris-Expressed Bivalent Virus-Like Particulate Vaccine Induces Domain III-Focused Bivalent Neutralizing Antibodies without Antibody-Dependent Enhancement in Vivo

Pichia pastoris-Expressed Bivalent Virus-Like Particulate Vaccine Induces Domain III-Focused Bivalent Neutralizing Antibodies without Antibody-Dependent Enhancement in Vivo

Dengue, a significant public health problem in several countries around the world, is caused by four different serotypes of mosquito-borne dengue viruses (DENV-1, -2, -3, and -4). Antibodies to any one DENV serotype which can protect against homotypic re-infection, do not offer heterotypic cross-pro...

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Bibliographic Details
Main Authors: Rahul Shukla, Ravi K. Rajpoot, Upasana Arora, Ankur Poddar, Sathyamangalam Swaminathan, Navin Khanna
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Microbiology
Subjects:
dengue virus
recombinant tetravalent vaccine
virus-like particle
envelope protein
antibodydependent enhancement
AG129 model
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02644/full

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