Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine

OBJETIVE: The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS: A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects...

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Main Authors: Salvador M. Serra, Ricardo Vivacqua C. Costa, Bianca Gouvêa Bastos, Kelb Bousquet Santos, Sérgio Henrique Rodolpho Ramalho, Antonio Claudio Lucas da Nóbrega
Format: Article
Language:English
Published: Sociedade Brasileira de Cardiologia (SBC) 2001-04-01
Series:Arquivos Brasileiros de Cardiologia
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400002
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spelling doaj-2eb43de80f474fa9bfdd6acd45181ae62020-11-25T00:04:07ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia0066-782X1678-41702001-04-0176427928410.1590/S0066-782X2001000400002Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmineSalvador M. SerraRicardo Vivacqua C. CostaBianca Gouvêa BastosKelb Bousquet SantosSérgio Henrique Rodolpho RamalhoAntonio Claudio Lucas da NóbregaOBJETIVE: The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS: A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects who underwent three exercise stress tests (the first for adaptation and determination of tolerance to exercise, the other two after administration of placebo or 45mg of PYR). RESULTS: Heart rate at rest was: 68±3 vs 68±3bpm before and after placebo, respectively (P=0.38); 70±2 vs 59±2bpm, before and after pyridostigmine, respectively (P<0.01). During exercise, relative to placebo: a significantly lower heart rate after PYR at, respectively, 20% (P=0.02), 40% (P=0.03), 80% (P=0.05) and 100% (P=0.02) of peak effort was observed. No significant differences were observed in arterial blood pressure, oxygen consumption at submaximal and maximal effort, exercise duration, respiratory ratio, CO2 production, ventilation threshold, minute ventilation, and oxygen pulse. CONCLUSION: Pyridostigmine, at a dose of 45mg, decreases heart rate at rest and during exercise, with minimal side effects and without interfering with exercise tolerance and ventilation variables.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400002autonomic nervous systempyridostigmineexercise stress testing
collection DOAJ
language English
format Article
sources DOAJ
author Salvador M. Serra
Ricardo Vivacqua C. Costa
Bianca Gouvêa Bastos
Kelb Bousquet Santos
Sérgio Henrique Rodolpho Ramalho
Antonio Claudio Lucas da Nóbrega
spellingShingle Salvador M. Serra
Ricardo Vivacqua C. Costa
Bianca Gouvêa Bastos
Kelb Bousquet Santos
Sérgio Henrique Rodolpho Ramalho
Antonio Claudio Lucas da Nóbrega
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine
Arquivos Brasileiros de Cardiologia
autonomic nervous system
pyridostigmine
exercise stress testing
author_facet Salvador M. Serra
Ricardo Vivacqua C. Costa
Bianca Gouvêa Bastos
Kelb Bousquet Santos
Sérgio Henrique Rodolpho Ramalho
Antonio Claudio Lucas da Nóbrega
author_sort Salvador M. Serra
title Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine
title_short Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine
title_full Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine
title_fullStr Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine
title_full_unstemmed Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine
title_sort exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine
publisher Sociedade Brasileira de Cardiologia (SBC)
series Arquivos Brasileiros de Cardiologia
issn 0066-782X
1678-4170
publishDate 2001-04-01
description OBJETIVE: The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS: A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects who underwent three exercise stress tests (the first for adaptation and determination of tolerance to exercise, the other two after administration of placebo or 45mg of PYR). RESULTS: Heart rate at rest was: 68±3 vs 68±3bpm before and after placebo, respectively (P=0.38); 70±2 vs 59±2bpm, before and after pyridostigmine, respectively (P<0.01). During exercise, relative to placebo: a significantly lower heart rate after PYR at, respectively, 20% (P=0.02), 40% (P=0.03), 80% (P=0.05) and 100% (P=0.02) of peak effort was observed. No significant differences were observed in arterial blood pressure, oxygen consumption at submaximal and maximal effort, exercise duration, respiratory ratio, CO2 production, ventilation threshold, minute ventilation, and oxygen pulse. CONCLUSION: Pyridostigmine, at a dose of 45mg, decreases heart rate at rest and during exercise, with minimal side effects and without interfering with exercise tolerance and ventilation variables.
topic autonomic nervous system
pyridostigmine
exercise stress testing
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400002
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