Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine
OBJETIVE: The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS: A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects...
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Sociedade Brasileira de Cardiologia (SBC)
2001-04-01
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400002 |
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doaj-2eb43de80f474fa9bfdd6acd45181ae62020-11-25T00:04:07ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia0066-782X1678-41702001-04-0176427928410.1590/S0066-782X2001000400002Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmineSalvador M. SerraRicardo Vivacqua C. CostaBianca Gouvêa BastosKelb Bousquet SantosSérgio Henrique Rodolpho RamalhoAntonio Claudio Lucas da NóbregaOBJETIVE: The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS: A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects who underwent three exercise stress tests (the first for adaptation and determination of tolerance to exercise, the other two after administration of placebo or 45mg of PYR). RESULTS: Heart rate at rest was: 68±3 vs 68±3bpm before and after placebo, respectively (P=0.38); 70±2 vs 59±2bpm, before and after pyridostigmine, respectively (P<0.01). During exercise, relative to placebo: a significantly lower heart rate after PYR at, respectively, 20% (P=0.02), 40% (P=0.03), 80% (P=0.05) and 100% (P=0.02) of peak effort was observed. No significant differences were observed in arterial blood pressure, oxygen consumption at submaximal and maximal effort, exercise duration, respiratory ratio, CO2 production, ventilation threshold, minute ventilation, and oxygen pulse. CONCLUSION: Pyridostigmine, at a dose of 45mg, decreases heart rate at rest and during exercise, with minimal side effects and without interfering with exercise tolerance and ventilation variables.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400002autonomic nervous systempyridostigmineexercise stress testing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Salvador M. Serra Ricardo Vivacqua C. Costa Bianca Gouvêa Bastos Kelb Bousquet Santos Sérgio Henrique Rodolpho Ramalho Antonio Claudio Lucas da Nóbrega |
spellingShingle |
Salvador M. Serra Ricardo Vivacqua C. Costa Bianca Gouvêa Bastos Kelb Bousquet Santos Sérgio Henrique Rodolpho Ramalho Antonio Claudio Lucas da Nóbrega Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine Arquivos Brasileiros de Cardiologia autonomic nervous system pyridostigmine exercise stress testing |
author_facet |
Salvador M. Serra Ricardo Vivacqua C. Costa Bianca Gouvêa Bastos Kelb Bousquet Santos Sérgio Henrique Rodolpho Ramalho Antonio Claudio Lucas da Nóbrega |
author_sort |
Salvador M. Serra |
title |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
title_short |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
title_full |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
title_fullStr |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
title_full_unstemmed |
Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
title_sort |
exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine |
publisher |
Sociedade Brasileira de Cardiologia (SBC) |
series |
Arquivos Brasileiros de Cardiologia |
issn |
0066-782X 1678-4170 |
publishDate |
2001-04-01 |
description |
OBJETIVE: The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS: A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects who underwent three exercise stress tests (the first for adaptation and determination of tolerance to exercise, the other two after administration of placebo or 45mg of PYR). RESULTS: Heart rate at rest was: 68±3 vs 68±3bpm before and after placebo, respectively (P=0.38); 70±2 vs 59±2bpm, before and after pyridostigmine, respectively (P<0.01). During exercise, relative to placebo: a significantly lower heart rate after PYR at, respectively, 20% (P=0.02), 40% (P=0.03), 80% (P=0.05) and 100% (P=0.02) of peak effort was observed. No significant differences were observed in arterial blood pressure, oxygen consumption at submaximal and maximal effort, exercise duration, respiratory ratio, CO2 production, ventilation threshold, minute ventilation, and oxygen pulse. CONCLUSION: Pyridostigmine, at a dose of 45mg, decreases heart rate at rest and during exercise, with minimal side effects and without interfering with exercise tolerance and ventilation variables. |
topic |
autonomic nervous system pyridostigmine exercise stress testing |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400002 |
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