Immunosuppression of Syrian golden hamsters accelerates relapse but not the emergence of resistance in Leishmania infantum following recurrent miltefosine pressure
Although miltefosine (MIL) has only been approved for the treatment of visceral leishmaniasis (VL) in 2002, its application in monotherapy already led to the development of two confirmed MIL-resistant isolates by 2009. Although liposomal amphotericin B is recommended as first-line treatment in Europ...
Main Authors: | S. Hendrickx, D. Bulté, M. Van den Kerkhof, P. Cos, P. Delputte, L. Maes, G. Caljon |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-04-01
|
Series: | International Journal for Parasitology: Drugs and Drug Resistance |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221132071830160X |
Similar Items
-
Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum.
by: Sarah Hendrickx, et al.
Published: (2017-05-01) -
Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition.
by: Dimitri Bulté, et al.
Published: (2021-07-01) -
Impact of clinically acquired miltefosine resistance by Leishmania infantum on mouse and sand fly infection
by: Lieselotte Van Bockstal, et al.
Published: (2020-08-01) -
Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.
by: Annelies Mondelaers, et al.
Published: (2016-01-01) -
Impaired development of a miltefosine-resistant Leishmania infantum strain in the sand fly vectors Phlebotomus perniciosus and Lutzomyia longipalpis
by: Lieselotte Van Bockstal, et al.
Published: (2019-12-01)