α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3
Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3–6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected f...
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| Language: | English |
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MDPI AG
2018-09-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/9/307 |
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doaj-2ea7c434b49a429db8d2fedd3ea8b61a2020-11-24T22:20:07ZengMDPI AGMarine Drugs1660-33972018-09-0116930710.3390/md16090307md16090307α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3Yingnan Wu0Yan Chen1Xishan Huang2Yahong Pan3Zhaoming Liu4Tao Yan5Wenhao Cao6Zhigang She7School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaSouth China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, School of Marine Sciences, Sun Yat-Sen University, Guangzhou 510006, ChinaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaTwo new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3–6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the province of Guangdong, China. The structures of compounds 1–6 were determined by analyzing NMR and HRESIMS data. The absolute configurations of 5 and 6 were assigned by comparing their experimental ECD spectra with those reported for similar compounds in the literature. All isolates were evaluated for their α-glucosidase inhibitory activity, of which compounds 3, 5, 10, and 11 showed strong inhibitory effects with IC50 values in the range of 1.5–4.5 μM.http://www.mdpi.com/1660-3397/16/9/307α-glucosidase inhibitorsmangrove endophytic fungusAspergillus flavus |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yingnan Wu Yan Chen Xishan Huang Yahong Pan Zhaoming Liu Tao Yan Wenhao Cao Zhigang She |
| spellingShingle |
Yingnan Wu Yan Chen Xishan Huang Yahong Pan Zhaoming Liu Tao Yan Wenhao Cao Zhigang She α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3 Marine Drugs α-glucosidase inhibitors mangrove endophytic fungus Aspergillus flavus |
| author_facet |
Yingnan Wu Yan Chen Xishan Huang Yahong Pan Zhaoming Liu Tao Yan Wenhao Cao Zhigang She |
| author_sort |
Yingnan Wu |
| title |
α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3 |
| title_short |
α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3 |
| title_full |
α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3 |
| title_fullStr |
α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3 |
| title_full_unstemmed |
α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3 |
| title_sort |
α-glucosidase inhibitors: diphenyl ethers and phenolic bisabolane sesquiterpenoids from the mangrove endophytic fungus aspergillus flavus qqsg-3 |
| publisher |
MDPI AG |
| series |
Marine Drugs |
| issn |
1660-3397 |
| publishDate |
2018-09-01 |
| description |
Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3–6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the province of Guangdong, China. The structures of compounds 1–6 were determined by analyzing NMR and HRESIMS data. The absolute configurations of 5 and 6 were assigned by comparing their experimental ECD spectra with those reported for similar compounds in the literature. All isolates were evaluated for their α-glucosidase inhibitory activity, of which compounds 3, 5, 10, and 11 showed strong inhibitory effects with IC50 values in the range of 1.5–4.5 μM. |
| topic |
α-glucosidase inhibitors mangrove endophytic fungus Aspergillus flavus |
| url |
http://www.mdpi.com/1660-3397/16/9/307 |
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