LiHMDS: Facile, highly efficient and metal-free transesterification under solvent-free condition

• Main Authors: Lavanya L. Mittapelli, Kiran R. Gore
• Format: Article
• Language: English
• Published: Elsevier 2021-01-01
• Series: Catalysis Communications
• Subjects: Transesterification; Transition metal-free; Solvent-free; LiHMDS; Benzoate ester
• Online Access: http://www.sciencedirect.com/science/article/pii/S1566736720302703

Transesterification is one of the important organic reactions employed in numerous industrial as well as laboratory applications for the synthesis of various esters. Herein, we report a rapid, highly efficient, and transition metal-free transesterification reaction in the presence of LiHMDS under solvent-free conditions. The transesterification reaction was carried out with three different benzoate esters and a wide range of primary and secondary alcohols (from C3-C18) in good to excellent yields (45 examples). By considering the commercial role of esters, this method will be promising for the facile synthesis of esters in industry-relevant applications.