inv (4)(p13q13) in patient with essential thrombocythemia: A case report

inv (4)(p13q13) in patient with essential thrombocythemia: A case report

The inv (4)(p13q13) cytogenetic abnormality is uncommon in hematologic malignancies. So far, it has not been previously reported in patients with essential thrombocythemia (ET). We report a first case of ET with inv (4)(p13q13) karyotype in a 69-year-old female patient who developed myelofibrosis at...

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Main Authors: Cigdem Aydin, Ozan Salim, Orhan Kemal Yucel, Levent Undar, Sibel Berker Karauzum
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Hematology/Oncology and Stem Cell Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1658387615000308
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spelling doaj-2e9b5796943946739bc8f1a6cafc98182020-11-25T00:33:25ZengElsevierHematology/Oncology and Stem Cell Therapy1658-38762015-12-0184181184inv (4)(p13q13) in patient with essential thrombocythemia: A case reportCigdem Aydin0Ozan Salim1Orhan Kemal Yucel2Levent Undar3Sibel Berker Karauzum4Mehmet Akif Ersoy University, Bucak School of Health, Department of Nursing, Burdur, TurkeyAkdeniz University, Faculty of Medicine, Department of Hematology, Antalya, TurkeyAkdeniz University, Faculty of Medicine, Department of Hematology, Antalya, TurkeyAkdeniz University, Faculty of Medicine, Department of Hematology, Antalya, TurkeyAkdeniz University, Faculty of Medicine, Department of Medical Biology and Genetics, Antalya, Turkey; Corresponding author. Tel.: +90 242 249 69 70.The inv (4)(p13q13) cytogenetic abnormality is uncommon in hematologic malignancies. So far, it has not been previously reported in patients with essential thrombocythemia (ET). We report a first case of ET with inv (4)(p13q13) karyotype in a 69-year-old female patient who developed myelofibrosis at follow up. Conventional cytogenetic analysis from a bone marrow sample showed 46, XX, inv (4)(p13q13) [3]/46, XX [4] at diagnosis and subsequent analysis revealed the same abnormal karyotype during the myelofibrosis phase (46, XX, inv (4)(p13q13) [13]/46, XX [26]). The prognostic significance of this chromosomal abnormality is unknown. Keywords: Essential thrombocythemia, Myeloproliferative disorder, inv (4)(p13q13)http://www.sciencedirect.com/science/article/pii/S1658387615000308
collection DOAJ
language English
format Article
sources DOAJ
author Cigdem Aydin
Ozan Salim
Orhan Kemal Yucel
Levent Undar
Sibel Berker Karauzum
spellingShingle Cigdem Aydin
Ozan Salim
Orhan Kemal Yucel
Levent Undar
Sibel Berker Karauzum
inv (4)(p13q13) in patient with essential thrombocythemia: A case report
Hematology/Oncology and Stem Cell Therapy
author_facet Cigdem Aydin
Ozan Salim
Orhan Kemal Yucel
Levent Undar
Sibel Berker Karauzum
author_sort Cigdem Aydin
title inv (4)(p13q13) in patient with essential thrombocythemia: A case report
title_short inv (4)(p13q13) in patient with essential thrombocythemia: A case report
title_full inv (4)(p13q13) in patient with essential thrombocythemia: A case report
title_fullStr inv (4)(p13q13) in patient with essential thrombocythemia: A case report
title_full_unstemmed inv (4)(p13q13) in patient with essential thrombocythemia: A case report
title_sort inv (4)(p13q13) in patient with essential thrombocythemia: a case report
publisher Elsevier
series Hematology/Oncology and Stem Cell Therapy
issn 1658-3876
publishDate 2015-12-01
description The inv (4)(p13q13) cytogenetic abnormality is uncommon in hematologic malignancies. So far, it has not been previously reported in patients with essential thrombocythemia (ET). We report a first case of ET with inv (4)(p13q13) karyotype in a 69-year-old female patient who developed myelofibrosis at follow up. Conventional cytogenetic analysis from a bone marrow sample showed 46, XX, inv (4)(p13q13) [3]/46, XX [4] at diagnosis and subsequent analysis revealed the same abnormal karyotype during the myelofibrosis phase (46, XX, inv (4)(p13q13) [13]/46, XX [26]). The prognostic significance of this chromosomal abnormality is unknown. Keywords: Essential thrombocythemia, Myeloproliferative disorder, inv (4)(p13q13)
url http://www.sciencedirect.com/science/article/pii/S1658387615000308
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AT orhankemalyucel inv4p13q13inpatientwithessentialthrombocythemiaacasereport
AT leventundar inv4p13q13inpatientwithessentialthrombocythemiaacasereport
AT sibelberkerkarauzum inv4p13q13inpatientwithessentialthrombocythemiaacasereport
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