Molecular Insights into Mitochondrial Protein Translocation and Human Disease

Molecular Insights into Mitochondrial Protein Translocation and Human Disease

In human mitochondria, mtDNA encodes for only 13 proteins, all components of the OXPHOS system. The rest of the mitochondrial components, which make up approximately 99% of its proteome, are encoded in the nuclear genome, synthesized in cytosolic ribosomes and imported into mitochondria. Different i...

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Bibliographic Details
Main Authors: Eduardo Ruiz-Pesini, Julio Montoya, David Pacheu-Grau
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Genes
Subjects:
mitochondria
protein import
disease
Online Access:https://www.mdpi.com/2073-4425/12/7/1031

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