Immune Repertoire after Immunization As Seen by Next-Generation Sequencing and Proteomics

Immune Repertoire after Immunization As Seen by Next-Generation Sequencing and Proteomics

The immune system produces a diverse repertoire of immunoglobulins in response to foreign antigens. During B-cell development, VDJ recombination and somatic mutations generate diversity, whereas selection processes remove it. Using both proteomic and NGS approaches, we characterized the immune reper...

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Bibliographic Details
Main Authors: Martijn M. VanDuijn, Lennard J. Dekker, Wilfred F. J. van IJcken, Peter A. E. Sillevis Smitt, Theo M. Luider
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
immune repertoire
immunization
NGS
mass spectrometry
immunoglobulins
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01286/full

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