LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells

LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells

Long non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented. In this study, we found that HOXA11-AS expression was upregulated in non–small cell lung cancer tissues and cell lines. High levels of HOXA11-AS expression were correlated with larger tu...

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Main Authors: Wanjun Yu, Weidong Peng, Hao Jiang, Hanyun Sha, Jipeng Li
Format: Article
Language:English
Published: IOS Press 2017-10-01
Series:Tumor Biology
Online Access:https://doi.org/10.1177/1010428317721440
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spelling doaj-2e792cc0d017488d92e360f654f33f1a2021-05-02T18:12:53ZengIOS PressTumor Biology1423-03802017-10-013910.1177/1010428317721440LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cellsWanjun Yu0Weidong Peng1Hao Jiang2Hanyun Sha3Jipeng Li4Department of Respiratory and Critical Care Medicine, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, ChinaDepartment of Respiratory and Critical Care Medicine, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, ChinaDepartment of Respiratory and Critical Care Medicine, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, ChinaDepartment of Nephrology, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, ChinaDepartment of Central Laboratory, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, ChinaLong non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented. In this study, we found that HOXA11-AS expression was upregulated in non–small cell lung cancer tissues and cell lines. High levels of HOXA11-AS expression were correlated with larger tumor size and lymph node metastasis. Functional analysis revealed that HOXA11-AS promotes non–small cell lung cancer cell proliferation and invasion. In particular, HOXA11-AS functions as a competing endogenous RNA to regulate transcriptional factor Sp1 expression via sponging miR-124. Collectively, our findings reveal an oncogenic role for HOXA11-AS in non–small cell lung cancer tumorigenesis.https://doi.org/10.1177/1010428317721440
collection DOAJ
language English
format Article
sources DOAJ
author Wanjun Yu
Weidong Peng
Hao Jiang
Hanyun Sha
Jipeng Li
spellingShingle Wanjun Yu
Weidong Peng
Hao Jiang
Hanyun Sha
Jipeng Li
LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells
Tumor Biology
author_facet Wanjun Yu
Weidong Peng
Hao Jiang
Hanyun Sha
Jipeng Li
author_sort Wanjun Yu
title LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells
title_short LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells
title_full LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells
title_fullStr LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells
title_full_unstemmed LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells
title_sort lncrna hoxa11-as promotes proliferation and invasion by targeting mir-124 in human non–small cell lung cancer cells
publisher IOS Press
series Tumor Biology
issn 1423-0380
publishDate 2017-10-01
description Long non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented. In this study, we found that HOXA11-AS expression was upregulated in non–small cell lung cancer tissues and cell lines. High levels of HOXA11-AS expression were correlated with larger tumor size and lymph node metastasis. Functional analysis revealed that HOXA11-AS promotes non–small cell lung cancer cell proliferation and invasion. In particular, HOXA11-AS functions as a competing endogenous RNA to regulate transcriptional factor Sp1 expression via sponging miR-124. Collectively, our findings reveal an oncogenic role for HOXA11-AS in non–small cell lung cancer tumorigenesis.
url https://doi.org/10.1177/1010428317721440
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AT weidongpeng lncrnahoxa11aspromotesproliferationandinvasionbytargetingmir124inhumannonsmallcelllungcancercells
AT haojiang lncrnahoxa11aspromotesproliferationandinvasionbytargetingmir124inhumannonsmallcelllungcancercells
AT hanyunsha lncrnahoxa11aspromotesproliferationandinvasionbytargetingmir124inhumannonsmallcelllungcancercells
AT jipengli lncrnahoxa11aspromotesproliferationandinvasionbytargetingmir124inhumannonsmallcelllungcancercells
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