Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus

Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus

Zika virus (ZIKV), a flavivirus with homology to dengue virus (DENV), is spreading to areas of DENV hyper-endemicity. Heterologous T cell immunity, whereby virus-specific memory T cells are activated by variant peptides derived from a different virus, can lead to enhanced viral clearance or diminish...

Full description

Bibliographic Details
Main Authors: Mei Qiu Lim, Emmanuelle A. P. Kumaran, Hwee Cheng Tan, David C. Lye, Yee Sin Leo, Eng Eong Ooi, Paul A. MacAry, Antonio Bertoletti, Laura Rivino
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
dengue virus (DENV)
Zika virus (ZIKV)
T cells
cross-reactive immune response
heterologous immunity
anti-viral response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02225/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02225/full

Similar Items