| Summary: | The FINNOVER project provides a technical and economic path for the creation of new supply chains, or their development, for the sustainable extraction and utilization of natural biologically active molecules. In this research, a green extraction method and re-use strategy of botanical by-products are developed and used to obtain value-added products as an ecological alternative to waste composting or incineration. It was applied to the production of<i> Castanea </i>spp. bud-derivatives (a specific category of food supplements derived from plant material) and their by-products. This study aimed to compare the phytochemical composition of <i>Castanea </i>spp. bud-preparations (herbal preparations from buds and sprouts) with the extracts derived from the bud-waste management process. Bioactive compounds were extracted by maceration in hydroglyceroalcoholic solution (traditional method) and by a green extraction technique (Pulsed Ultrasound-Assisted Extraction—PUAE) and identified and quantified by HPLC methods obtaining a specific chromatographic profile. PUAE extracted a total content of 160.42 mg/100 g FW, a good amount if compared to the relative commercial product (1276.17 mg/100 g FW). About 13% of the chemical content of <i>Castanea </i>spp. bud-preparations was maintained in the by-product extracts. This research showed that PUAE may be considered as a sustainable alternative to waste management based on incineration or composting. This study could be considered by the industries for the development of new products for the market derived from the bud-derivative processing waste.
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