Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice

Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice

T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans and non-obese diabetic (NOD) mice that spontaneously develop autoimmune diabetes. Mice have two proinsulin genes proinsulin -1 and 2 that are differentially expressed, with predominant proinsulin-2 e...

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Bibliographic Details
Main Authors: Gaurang Jhala, Claudia Selck, Jonathan Chee, Chun-Ting J. Kwong, Evan G. Pappas, Helen E. Thomas, Thomas W.H. Kay, Balasubramanian Krishnamurthy
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
proinsulin-1
CD4+ T cells
immune tolerance
NOD mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.645817/full

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