Modelling cell-cell collision and adhesion with the filament based lamellipodium model

Modelling cell-cell collision and adhesion with the filament based lamellipodium model

We extend the live-cell motility Filament Based Lamellipodium Model (FBLM) to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints a...

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Bibliographic Details
Main Authors: Nikolaos Sfakianakis, Diane Peurichard, Aaron Brunk, Christian Schmeiser
Format: Article
Language:English
Published: Biomath Forum 2018-11-01
Series:Biomath
Online Access:http://www.biomathforum.org/biomath/index.php/biomath/article/view/1278
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spelling doaj-2e48d0e45ff44e6dadb9bc7134c09d702020-11-25T02:43:15ZengBiomath ForumBiomath1314-684X1314-72182018-11-017210.11145/j.biomath.2018.11.097806Modelling cell-cell collision and adhesion with the filament based lamellipodium modelNikolaos Sfakianakis0Diane PeurichardAaron BrunkChristian SchmeiserHeidelberg UniversityWe extend the live-cell motility Filament Based Lamellipodium Model (FBLM) to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new components have in the migration and morphology of the cells through particular experiments. We exhibit moreover the similarities between our simulated cells and HeLa cancer cells.http://www.biomathforum.org/biomath/index.php/biomath/article/view/1278
collection DOAJ
language English
format Article
sources DOAJ
author Nikolaos Sfakianakis
Diane Peurichard
Aaron Brunk
Christian Schmeiser
spellingShingle Nikolaos Sfakianakis
Diane Peurichard
Aaron Brunk
Christian Schmeiser
Modelling cell-cell collision and adhesion with the filament based lamellipodium model
Biomath
author_facet Nikolaos Sfakianakis
Diane Peurichard
Aaron Brunk
Christian Schmeiser
author_sort Nikolaos Sfakianakis
title Modelling cell-cell collision and adhesion with the filament based lamellipodium model
title_short Modelling cell-cell collision and adhesion with the filament based lamellipodium model
title_full Modelling cell-cell collision and adhesion with the filament based lamellipodium model
title_fullStr Modelling cell-cell collision and adhesion with the filament based lamellipodium model
title_full_unstemmed Modelling cell-cell collision and adhesion with the filament based lamellipodium model
title_sort modelling cell-cell collision and adhesion with the filament based lamellipodium model
publisher Biomath Forum
series Biomath
issn 1314-684X
1314-7218
publishDate 2018-11-01
description We extend the live-cell motility Filament Based Lamellipodium Model (FBLM) to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new components have in the migration and morphology of the cells through particular experiments. We exhibit moreover the similarities between our simulated cells and HeLa cancer cells.
url http://www.biomathforum.org/biomath/index.php/biomath/article/view/1278
work_keys_str_mv AT nikolaossfakianakis modellingcellcellcollisionandadhesionwiththefilamentbasedlamellipodiummodel
AT dianepeurichard modellingcellcellcollisionandadhesionwiththefilamentbasedlamellipodiummodel
AT aaronbrunk modellingcellcellcollisionandadhesionwiththefilamentbasedlamellipodiummodel
AT christianschmeiser modellingcellcellcollisionandadhesionwiththefilamentbasedlamellipodiummodel
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