Integration of genetic and metabolic features related to sialic acid metabolism distinguishes human breast cell subtypes.

Integration of genetic and metabolic features related to sialic acid metabolism distinguishes human breast cell subtypes.

In this report we use 'high-flux' tributanoyl-modified N-acetylmannosamine (ManNAc) analogs with natural N-acetyl as well as non-natural azido- and alkyne N-acyl groups (specifically, 1,3,4-O-Bu3ManNAc, 1,3,4-O-Bu3ManNAz, and 1,3,4-O-Bu3ManNAl respectively) to probe intracellular sialic ac...

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Main Authors: Christopher T Saeui, Alison V Nairn, Melina Galizzi, Christopher Douville, Prateek Gowda, Marian Park, Vrinda Dharmarha, Sagar R Shah, Amelia Clarke, Melissa Austin, Kelley W Moremen, Kevin J Yarema
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5976204?pdf=render

Internet

http://europepmc.org/articles/PMC5976204?pdf=render

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