Human breast tumor cells are more resistant to cardiac glycoside toxicity than non-tumorigenic breast cells.

Human breast tumor cells are more resistant to cardiac glycoside toxicity than non-tumorigenic breast cells.

Cardiotonic steroids (CTS), specific inhibitors of Na,K-ATPase activity, have been widely used for treating cardiac insufficiency. Recent studies suggest that low levels of endogenous CTS do not inhibit Na,K-ATPase activity but play a role in regulating blood pressure, inducing cellular kinase activ...

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Bibliographic Details
Main Authors: Rebecca J Clifford, Jack H Kaplan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3862803?pdf=render

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