Correction of cardiovascular disorders in diabetic patients with depressive simptoms

• Main Authors: M. I Kolyadich, I. I Shaposhnik
• Format: Article
• Language: English
• Published: Concilium Medicum 2013-06-01
• Series: КардиоСоматика
• Subjects: diabetes mellitus; depression; diastolic myocardial dysfunction; pulmonary artery pressure; cardiovascular autonomic dysfunction; qt-interval; mexidol; a-lipoic acid
• Online Access: https://cardiosomatics.orscience.ru/2221-7185/article/view/44990

We studied the influence of mexidol and a-lipoic acid on cardiovascular and affective disorders' severity in patients with diabetes. 14-day administration of mexidol (300 mg/day) and a-lipoic acid (600 mg/day) had a positive impact on depressive guilt dinamics in association with a decrease in QTn-interval duration. Moreover, mexidol decreased patients' propencity to postural hypotension, and alfa-lipoic acid corrected myocardial diastolic function, pulmonary blood flow and circadian glycemia.