A Comparative Endocrine Trans-Differentiation Approach to Pancreatic Ductal Adenocarcinoma Cells with Different EMT Phenotypes Identifies Quasi-Mesenchymal Tumor Cells as Those with Highest Plasticity

A Comparative Endocrine Trans-Differentiation Approach to Pancreatic Ductal Adenocarcinoma Cells with Different EMT Phenotypes Identifies Quasi-Mesenchymal Tumor Cells as Those with Highest Plasticity

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and therapy-resistant cancer types which is largely due to tumor heterogeneity, cancer cell de-differentiation, and early metastatic spread. The major molecular subtypes of PDAC are designated classical/epithelial (E) and quasi-me...

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Bibliographic Details
Main Authors: Paula M. Schmidtlein, Clara Volz, Rüdiger Braun, Isabel Thürling, Olha Lapshyna, Ulrich F. Wellner, Björn Konukiewitz, Hendrik Lehnert, Jens-Uwe Marquardt, Hendrik Ungefroren
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
plasticity
quasi-mesenchymal
epithelial
trans-differentiation
endocrine
Online Access:https://www.mdpi.com/2072-6694/13/18/4663

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