REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA

Methylated analogs of L-arginine - asymmetric dimetilarginin (ADMA) and monometilarginin (L-NMMA) - are endogenous inhibitors of endothelial NO-synthase (eNOS). ADMA level in maternal plasma is increased in women with preeclampsia. The high level of ADMA is one of the predictors of preeclampsia. L-a...

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Main Authors:	M. V. Pokrovsky, N. G. Filipenko, M. V. Korokin, V. V. Gureyev, T. G. Pokrovsky, A. A. Barsuk, L. V. Korokina, E. V. Proskuryakova, N. V. Maltseva, O. V. Levashova, O. S. Gudyrev, A. S. Belous, O. S. Polyanskaya
Format:	Article
Language:	English
Published:	Stolichnaya Izdatelskaya Kompaniya 2016-01-01
Series:	Racionalʹnaâ Farmakoterapiâ v Kardiologii
Subjects:	endothelial dysfunction preeclampsia adma enos
Online Access:	https://www.rpcardio.com/jour/article/view/938

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spelling	doaj-2e2d0fe97be247eeb5bcd3a592b1aee32021-09-03T13:15:22ZengStolichnaya Izdatelskaya KompaniyaRacionalʹnaâ Farmakoterapiâ v Kardiologii1819-64462225-36532016-01-016688288710.20996/1819-6446-2010-6-6-882-887937REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIAM. V. Pokrovsky0N. G. Filipenko1M. V. Korokin2V. V. Gureyev3T. G. Pokrovsky4A. A. Barsuk5L. V. Korokina6E. V. Proskuryakova7N. V. Maltseva8O. V. Levashova9O. S. Gudyrev10A. S. Belous11O. S. Polyanskaya12Kursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityMethylated analogs of L-arginine - asymmetric dimetilarginin (ADMA) and monometilarginin (L-NMMA) - are endogenous inhibitors of endothelial NO-synthase (eNOS). ADMA level in maternal plasma is increased in women with preeclampsia. The high level of ADMA is one of the predictors of preeclampsia. L-arginine increases the activity of eNOS and production of nitric oxide in the ADMA-similar model of L-NAME-induced endothelial dysfunction. ENOS activator (resveratrol), antioxidants, potentiated polyclonal antibodies to eNOS and others agents have been effective in this model. Studies of endotelioprotective activity in other «ADMA-eNOS-associated" experimental models of metabolic syndrome and homocysteine-induced, gipoestrogen-induced sepsis-induced endothelial dysfunction and endothelial dysfunction in postvaccinal vasculitis have been developed.https://www.rpcardio.com/jour/article/view/938endothelial dysfunctionpreeclampsiaadmaenos
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	M. V. Pokrovsky N. G. Filipenko M. V. Korokin V. V. Gureyev T. G. Pokrovsky A. A. Barsuk L. V. Korokina E. V. Proskuryakova N. V. Maltseva O. V. Levashova O. S. Gudyrev A. S. Belous O. S. Polyanskaya
spellingShingle	M. V. Pokrovsky N. G. Filipenko M. V. Korokin V. V. Gureyev T. G. Pokrovsky A. A. Barsuk L. V. Korokina E. V. Proskuryakova N. V. Maltseva O. V. Levashova O. S. Gudyrev A. S. Belous O. S. Polyanskaya REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA Racionalʹnaâ Farmakoterapiâ v Kardiologii endothelial dysfunction preeclampsia adma enos
author_facet	M. V. Pokrovsky N. G. Filipenko M. V. Korokin V. V. Gureyev T. G. Pokrovsky A. A. Barsuk L. V. Korokina E. V. Proskuryakova N. V. Maltseva O. V. Levashova O. S. Gudyrev A. S. Belous O. S. Polyanskaya
author_sort	M. V. Pokrovsky
title	REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA
title_short	REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA
title_full	REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA
title_fullStr	REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA
title_full_unstemmed	REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA
title_sort	realities and prospects for pharmacological correction of «adma-enos"-associated ways in preeclampsia
publisher	Stolichnaya Izdatelskaya Kompaniya
series	Racionalʹnaâ Farmakoterapiâ v Kardiologii
issn	1819-6446 2225-3653
publishDate	2016-01-01
description	Methylated analogs of L-arginine - asymmetric dimetilarginin (ADMA) and monometilarginin (L-NMMA) - are endogenous inhibitors of endothelial NO-synthase (eNOS). ADMA level in maternal plasma is increased in women with preeclampsia. The high level of ADMA is one of the predictors of preeclampsia. L-arginine increases the activity of eNOS and production of nitric oxide in the ADMA-similar model of L-NAME-induced endothelial dysfunction. ENOS activator (resveratrol), antioxidants, potentiated polyclonal antibodies to eNOS and others agents have been effective in this model. Studies of endotelioprotective activity in other «ADMA-eNOS-associated" experimental models of metabolic syndrome and homocysteine-induced, gipoestrogen-induced sepsis-induced endothelial dysfunction and endothelial dysfunction in postvaccinal vasculitis have been developed.
topic	endothelial dysfunction preeclampsia adma enos
url	https://www.rpcardio.com/jour/article/view/938
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REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA

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