Reconstructing tumor evolutionary histories and clone trees in polynomial-time with SubMARine.

Tumors contain multiple subpopulations of genetically distinct cancer cells. Reconstructing their evolutionary history can improve our understanding of how cancers develop and respond to treatment. Subclonal reconstruction methods cluster mutations into groups that co-occur within the same subpopula...

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Bibliographic Details
Main Authors: Linda K Sundermann, Jeff Wintersinger, Gunnar Rätsch, Jens Stoye, Quaid Morris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008400

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