Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al2O3 under inspection

Although a plethora of synthetic procedures mediated by KF-loaded aluminas is available in the literature, there is almost no data concerning the influence of parameters such as alumina modification or KF-loading on experimental results. Hence, the Pd-catalyzed, solvent-free Suzuki–Miyaura reaction...

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Main Authors:	Franziska Bernhardt, Ronald Trotzki, Tony Szuppa, Achim Stolle, Bernd Ondruschka
Format:	Article
Language:	English
Published:	Beilstein-Institut 2010-01-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	ball milling C–C coupling KF–Al2O3 palladium solid reagent system
Online Access:	https://doi.org/10.3762/bjoc.6.7

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spelling	doaj-2e2b90215a74478d9a3fb959b376a6a52021-02-02T01:38:28ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972010-01-0161710.3762/bjoc.6.71860-5397-6-7Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al2O3 under inspectionFranziska Bernhardt0Ronald Trotzki1Tony Szuppa2Achim Stolle3Bernd Ondruschka4Institute for Technical Chemistry and Environmental Chemistry, Friedrich-Schiller University Jena, Lessingstraße 12, D-07743 Jena, GermanyInstitute for Technical Chemistry and Environmental Chemistry, Friedrich-Schiller University Jena, Lessingstraße 12, D-07743 Jena, GermanyInstitute for Technical Chemistry and Environmental Chemistry, Friedrich-Schiller University Jena, Lessingstraße 12, D-07743 Jena, GermanyInstitute for Technical Chemistry and Environmental Chemistry, Friedrich-Schiller University Jena, Lessingstraße 12, D-07743 Jena, GermanyInstitute for Technical Chemistry and Environmental Chemistry, Friedrich-Schiller University Jena, Lessingstraße 12, D-07743 Jena, GermanyAlthough a plethora of synthetic procedures mediated by KF-loaded aluminas is available in the literature, there is almost no data concerning the influence of parameters such as alumina modification or KF-loading on experimental results. Hence, the Pd-catalyzed, solvent-free Suzuki–Miyaura reaction was chosen as model reaction to investigate the effect of the above mentioned parameters on the results of coupling reactions. The results from ball milling experiments led to the conclusion that self-prepared and commercially available KF–Al2O3 differ in water content. The higher the residual water content, the higher are the product yields.https://doi.org/10.3762/bjoc.6.7ball millingC–C couplingKF–Al2O3palladiumsolid reagent system
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Franziska Bernhardt Ronald Trotzki Tony Szuppa Achim Stolle Bernd Ondruschka
spellingShingle	Franziska Bernhardt Ronald Trotzki Tony Szuppa Achim Stolle Bernd Ondruschka Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al2O3 under inspection Beilstein Journal of Organic Chemistry ball milling C–C coupling KF–Al2O3 palladium solid reagent system
author_facet	Franziska Bernhardt Ronald Trotzki Tony Szuppa Achim Stolle Bernd Ondruschka
author_sort	Franziska Bernhardt
title	Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al2O3 under inspection
title_short	Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al2O3 under inspection
title_full	Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al2O3 under inspection
title_fullStr	Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al2O3 under inspection
title_full_unstemmed	Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al2O3 under inspection
title_sort	solvent-free and time-efficient suzuki–miyaura reaction in a ball mill: the solid reagent system kf–al2o3 under inspection
publisher	Beilstein-Institut
series	Beilstein Journal of Organic Chemistry
issn	1860-5397
publishDate	2010-01-01
description	Although a plethora of synthetic procedures mediated by KF-loaded aluminas is available in the literature, there is almost no data concerning the influence of parameters such as alumina modification or KF-loading on experimental results. Hence, the Pd-catalyzed, solvent-free Suzuki–Miyaura reaction was chosen as model reaction to investigate the effect of the above mentioned parameters on the results of coupling reactions. The results from ball milling experiments led to the conclusion that self-prepared and commercially available KF–Al2O3 differ in water content. The higher the residual water content, the higher are the product yields.
topic	ball milling C–C coupling KF–Al2O3 palladium solid reagent system
url	https://doi.org/10.3762/bjoc.6.7
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Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al2O3 under inspection

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