The PDAC Extracellular Matrix: A Review of the ECM Protein Composition, Tumor Cell Interaction, and Therapeutic Strategies

The PDAC Extracellular Matrix: A Review of the ECM Protein Composition, Tumor Cell Interaction, and Therapeutic Strategies

Pancreatic ductal adenocarcinoma (PDAC) is notorious for a dense fibrotic stroma that is interlaced with a collagen-based extracellular matrix (ECM) that plays an important role in tumor biology. Traditionally thought to only provide a physical barrier from host responses and systemic chemotherapy,...

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Bibliographic Details
Main Authors: Vincent M. Perez, Joseph F. Kearney, Jen Jen Yeh
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
pancreatic ductal adenocarcinoma
extracellular matrix
tumor microenvironment
proteome
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.751311/full

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