Cholangiocarcinoma with respect to IgG4 Reaction

IgG4 reactions marked by infiltration of IgG4-positive plasma cells in affected organs occur in cancer patients and in patients with IgG4-related diseases. Extrahepatic cholangiocarcinomas including gall bladder cancer are often accompanied by significant IgG4 reactions; these reactions show a negat...

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Main Authors: Kenichi Harada, Yasuni Nakanuma
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:International Journal of Hepatology
Online Access:http://dx.doi.org/10.1155/2014/803876
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spelling doaj-2e1110bf50b64e5bbbe8bd630d45cd752020-11-24T22:56:51ZengHindawi LimitedInternational Journal of Hepatology2090-34482090-34562014-01-01201410.1155/2014/803876803876Cholangiocarcinoma with respect to IgG4 ReactionKenichi Harada0Yasuni Nakanuma1Department of Human Pathology, Kanazawa University School of Medicine, Kanazawa 920-8640, JapanDepartment of Human Pathology, Kanazawa University School of Medicine, Kanazawa 920-8640, JapanIgG4 reactions marked by infiltration of IgG4-positive plasma cells in affected organs occur in cancer patients and in patients with IgG4-related diseases. Extrahepatic cholangiocarcinomas including gall bladder cancer are often accompanied by significant IgG4 reactions; these reactions show a negative correlation with CD8-positive cytotoxic T cells, suggesting that the evasion of immune surveillance is associated with cytotoxic T cells. The regulatory cytokine IL-10 may induce IgG4-positive plasma cell differentiation or promote B cell switching to IgG4 in the presence of IL-4. Cholangiocarcinoma cells may function as nonprofessional antigen presenting cells that indirectly induce IgG4 reactions via the IL-10-producing cells and/or these may act as Foxp3-positive and IL-10-producing cells that directly induce IgG4 reactions. Moreover, IgG4-related disease is a high-risk factor for cancer development; IgG4-related sclerosing cholangitis (IgG4-SC) cases associated with cholangiocarcinoma or its precursor lesion biliary intraepithelial neoplasia (BilIN) have been reported. IgG4-positive cell infiltration is an important finding of IgG4-SC but is not a histological hallmark of IgG4-SC. For the diagnosis of IgG4-SC, its differentiation from cholangiocarcinoma remains important.http://dx.doi.org/10.1155/2014/803876
collection DOAJ
language English
format Article
sources DOAJ
author Kenichi Harada
Yasuni Nakanuma
spellingShingle Kenichi Harada
Yasuni Nakanuma
Cholangiocarcinoma with respect to IgG4 Reaction
International Journal of Hepatology
author_facet Kenichi Harada
Yasuni Nakanuma
author_sort Kenichi Harada
title Cholangiocarcinoma with respect to IgG4 Reaction
title_short Cholangiocarcinoma with respect to IgG4 Reaction
title_full Cholangiocarcinoma with respect to IgG4 Reaction
title_fullStr Cholangiocarcinoma with respect to IgG4 Reaction
title_full_unstemmed Cholangiocarcinoma with respect to IgG4 Reaction
title_sort cholangiocarcinoma with respect to igg4 reaction
publisher Hindawi Limited
series International Journal of Hepatology
issn 2090-3448
2090-3456
publishDate 2014-01-01
description IgG4 reactions marked by infiltration of IgG4-positive plasma cells in affected organs occur in cancer patients and in patients with IgG4-related diseases. Extrahepatic cholangiocarcinomas including gall bladder cancer are often accompanied by significant IgG4 reactions; these reactions show a negative correlation with CD8-positive cytotoxic T cells, suggesting that the evasion of immune surveillance is associated with cytotoxic T cells. The regulatory cytokine IL-10 may induce IgG4-positive plasma cell differentiation or promote B cell switching to IgG4 in the presence of IL-4. Cholangiocarcinoma cells may function as nonprofessional antigen presenting cells that indirectly induce IgG4 reactions via the IL-10-producing cells and/or these may act as Foxp3-positive and IL-10-producing cells that directly induce IgG4 reactions. Moreover, IgG4-related disease is a high-risk factor for cancer development; IgG4-related sclerosing cholangitis (IgG4-SC) cases associated with cholangiocarcinoma or its precursor lesion biliary intraepithelial neoplasia (BilIN) have been reported. IgG4-positive cell infiltration is an important finding of IgG4-SC but is not a histological hallmark of IgG4-SC. For the diagnosis of IgG4-SC, its differentiation from cholangiocarcinoma remains important.
url http://dx.doi.org/10.1155/2014/803876
work_keys_str_mv AT kenichiharada cholangiocarcinomawithrespecttoigg4reaction
AT yasuninakanuma cholangiocarcinomawithrespecttoigg4reaction
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