Cholangiocarcinoma with respect to IgG4 Reaction
IgG4 reactions marked by infiltration of IgG4-positive plasma cells in affected organs occur in cancer patients and in patients with IgG4-related diseases. Extrahepatic cholangiocarcinomas including gall bladder cancer are often accompanied by significant IgG4 reactions; these reactions show a negat...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2014-01-01
|
Series: | International Journal of Hepatology |
Online Access: | http://dx.doi.org/10.1155/2014/803876 |
id |
doaj-2e1110bf50b64e5bbbe8bd630d45cd75 |
---|---|
record_format |
Article |
spelling |
doaj-2e1110bf50b64e5bbbe8bd630d45cd752020-11-24T22:56:51ZengHindawi LimitedInternational Journal of Hepatology2090-34482090-34562014-01-01201410.1155/2014/803876803876Cholangiocarcinoma with respect to IgG4 ReactionKenichi Harada0Yasuni Nakanuma1Department of Human Pathology, Kanazawa University School of Medicine, Kanazawa 920-8640, JapanDepartment of Human Pathology, Kanazawa University School of Medicine, Kanazawa 920-8640, JapanIgG4 reactions marked by infiltration of IgG4-positive plasma cells in affected organs occur in cancer patients and in patients with IgG4-related diseases. Extrahepatic cholangiocarcinomas including gall bladder cancer are often accompanied by significant IgG4 reactions; these reactions show a negative correlation with CD8-positive cytotoxic T cells, suggesting that the evasion of immune surveillance is associated with cytotoxic T cells. The regulatory cytokine IL-10 may induce IgG4-positive plasma cell differentiation or promote B cell switching to IgG4 in the presence of IL-4. Cholangiocarcinoma cells may function as nonprofessional antigen presenting cells that indirectly induce IgG4 reactions via the IL-10-producing cells and/or these may act as Foxp3-positive and IL-10-producing cells that directly induce IgG4 reactions. Moreover, IgG4-related disease is a high-risk factor for cancer development; IgG4-related sclerosing cholangitis (IgG4-SC) cases associated with cholangiocarcinoma or its precursor lesion biliary intraepithelial neoplasia (BilIN) have been reported. IgG4-positive cell infiltration is an important finding of IgG4-SC but is not a histological hallmark of IgG4-SC. For the diagnosis of IgG4-SC, its differentiation from cholangiocarcinoma remains important.http://dx.doi.org/10.1155/2014/803876 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kenichi Harada Yasuni Nakanuma |
spellingShingle |
Kenichi Harada Yasuni Nakanuma Cholangiocarcinoma with respect to IgG4 Reaction International Journal of Hepatology |
author_facet |
Kenichi Harada Yasuni Nakanuma |
author_sort |
Kenichi Harada |
title |
Cholangiocarcinoma with respect to IgG4 Reaction |
title_short |
Cholangiocarcinoma with respect to IgG4 Reaction |
title_full |
Cholangiocarcinoma with respect to IgG4 Reaction |
title_fullStr |
Cholangiocarcinoma with respect to IgG4 Reaction |
title_full_unstemmed |
Cholangiocarcinoma with respect to IgG4 Reaction |
title_sort |
cholangiocarcinoma with respect to igg4 reaction |
publisher |
Hindawi Limited |
series |
International Journal of Hepatology |
issn |
2090-3448 2090-3456 |
publishDate |
2014-01-01 |
description |
IgG4 reactions marked by infiltration of IgG4-positive plasma cells in affected organs occur in cancer patients and in patients with IgG4-related diseases. Extrahepatic cholangiocarcinomas including gall bladder cancer are often accompanied by significant IgG4 reactions; these reactions show a negative correlation with CD8-positive cytotoxic T cells, suggesting that the evasion of immune surveillance is associated with cytotoxic T cells. The regulatory cytokine IL-10 may induce IgG4-positive plasma cell differentiation or promote B cell switching to IgG4 in the presence of IL-4. Cholangiocarcinoma cells may function as nonprofessional antigen presenting cells that indirectly induce IgG4 reactions via the IL-10-producing cells and/or these may act as Foxp3-positive and IL-10-producing cells that directly induce IgG4 reactions. Moreover, IgG4-related disease is a high-risk factor for cancer development; IgG4-related sclerosing cholangitis (IgG4-SC) cases associated with cholangiocarcinoma or its precursor lesion biliary intraepithelial neoplasia (BilIN) have been reported. IgG4-positive cell infiltration is an important finding of IgG4-SC but is not a histological hallmark of IgG4-SC. For the diagnosis of IgG4-SC, its differentiation from cholangiocarcinoma remains important. |
url |
http://dx.doi.org/10.1155/2014/803876 |
work_keys_str_mv |
AT kenichiharada cholangiocarcinomawithrespecttoigg4reaction AT yasuninakanuma cholangiocarcinomawithrespecttoigg4reaction |
_version_ |
1725653032083914752 |