Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages

Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages

Macrophages are natural target cells of human immunodeficiency virus type 1 (HIV-1). Viral replication appears to be delayed in these cells compared to lymphocytes; however, little is known about the kinetics of early post-entry events. Time-of-addition experiments using several HIV-1 inhibitors and...

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Bibliographic Details
Main Authors: David Alejandro Bejarano, Maria C. Puertas, Kathleen Börner, Javier Martinez-Picado, Barbara Müller, Hans-Georg Kräusslich
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Viruses
Subjects:
human immunodeficiency virus
primary macrophages
reverse-transcription complex
pre-integration complex
replication kinetics
SAMHD1
Online Access:https://www.mdpi.com/1999-4915/10/11/620

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