Inhibition Lysosomal Degradation of Clusterin by Protein Kinase D3 Promotes Triple‐Negative Breast Cancer Tumor Growth

Inhibition Lysosomal Degradation of Clusterin by Protein Kinase D3 Promotes Triple‐Negative Breast Cancer Tumor Growth

Abstract Triple negative breast cancer (TNBC), with its lack of targeted therapies, shows the worst mortality rate among all breast cancer subtypes. Clusterin (CLU) is implicated to play important oncogenic roles in cancer via promoting various downstream oncogenic pathways. Here, protein kinase D3...

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Bibliographic Details
Main Authors: Yan Liu, Yehui Zhou, Xinxing Ma, Liming Chen
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Advanced Science
Subjects:
clusterin
protein kinase D3
targeted therapies
triple‐negative breast cancer
tumor growth
Online Access:https://doi.org/10.1002/advs.202003205

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