Techniques for Studying Decoding of Single Cell Dynamics

Cells must be able to interpret signals they encounter and reliably generate an appropriate response. It has long been known that the dynamics of transcription factor and kinase activation can play a crucial role in selecting an individual cell's response. The study of cellular dynamics has exp...

Full description

Bibliographic Details
Main Authors:	Stevan Jeknić, Takamasa Kudo, Markus W. Covert
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-04-01
Series:	Frontiers in Immunology
Subjects:	dynamics decoding encoding single cell signaling live cell microscopy
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00755/full

id	doaj-2e0425bef7754437bcf7a4fa46ad4d00
record_format	Article
spelling	doaj-2e0425bef7754437bcf7a4fa46ad4d002020-11-25T01:01:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-04-011010.3389/fimmu.2019.00755450218Techniques for Studying Decoding of Single Cell DynamicsStevan Jeknić0Stevan Jeknić1Takamasa Kudo2Takamasa Kudo3Markus W. Covert4Markus W. Covert5Markus W. Covert6Department of Bioengineering, Stanford University, Stanford, CA, United StatesAllen Discovery Center for Systems Modeling of Infection, Stanford, CA, United StatesAllen Discovery Center for Systems Modeling of Infection, Stanford, CA, United StatesDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, United StatesDepartment of Bioengineering, Stanford University, Stanford, CA, United StatesAllen Discovery Center for Systems Modeling of Infection, Stanford, CA, United StatesDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, United StatesCells must be able to interpret signals they encounter and reliably generate an appropriate response. It has long been known that the dynamics of transcription factor and kinase activation can play a crucial role in selecting an individual cell's response. The study of cellular dynamics has expanded dramatically in the last few years, with dynamics being discovered in novel pathways, new insights being revealed about the importance of dynamics, and technological improvements increasing the throughput and capabilities of single cell measurements. In this review, we highlight the important developments in this field, with a focus on the methods used to make new discoveries. We also include a discussion on improvements in methods for engineering and measuring single cell dynamics and responses. Finally, we will briefly highlight some of the many challenges and avenues of research that are still open.https://www.frontiersin.org/article/10.3389/fimmu.2019.00755/fulldynamicsdecodingencodingsingle cellsignalinglive cell microscopy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Stevan Jeknić Stevan Jeknić Takamasa Kudo Takamasa Kudo Markus W. Covert Markus W. Covert Markus W. Covert
spellingShingle	Stevan Jeknić Stevan Jeknić Takamasa Kudo Takamasa Kudo Markus W. Covert Markus W. Covert Markus W. Covert Techniques for Studying Decoding of Single Cell Dynamics Frontiers in Immunology dynamics decoding encoding single cell signaling live cell microscopy
author_facet	Stevan Jeknić Stevan Jeknić Takamasa Kudo Takamasa Kudo Markus W. Covert Markus W. Covert Markus W. Covert
author_sort	Stevan Jeknić
title	Techniques for Studying Decoding of Single Cell Dynamics
title_short	Techniques for Studying Decoding of Single Cell Dynamics
title_full	Techniques for Studying Decoding of Single Cell Dynamics
title_fullStr	Techniques for Studying Decoding of Single Cell Dynamics
title_full_unstemmed	Techniques for Studying Decoding of Single Cell Dynamics
title_sort	techniques for studying decoding of single cell dynamics
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2019-04-01
description	Cells must be able to interpret signals they encounter and reliably generate an appropriate response. It has long been known that the dynamics of transcription factor and kinase activation can play a crucial role in selecting an individual cell's response. The study of cellular dynamics has expanded dramatically in the last few years, with dynamics being discovered in novel pathways, new insights being revealed about the importance of dynamics, and technological improvements increasing the throughput and capabilities of single cell measurements. In this review, we highlight the important developments in this field, with a focus on the methods used to make new discoveries. We also include a discussion on improvements in methods for engineering and measuring single cell dynamics and responses. Finally, we will briefly highlight some of the many challenges and avenues of research that are still open.
topic	dynamics decoding encoding single cell signaling live cell microscopy
url	https://www.frontiersin.org/article/10.3389/fimmu.2019.00755/full
work_keys_str_mv	AT stevanjeknic techniquesforstudyingdecodingofsinglecelldynamics AT stevanjeknic techniquesforstudyingdecodingofsinglecelldynamics AT takamasakudo techniquesforstudyingdecodingofsinglecelldynamics AT takamasakudo techniquesforstudyingdecodingofsinglecelldynamics AT markuswcovert techniquesforstudyingdecodingofsinglecelldynamics AT markuswcovert techniquesforstudyingdecodingofsinglecelldynamics AT markuswcovert techniquesforstudyingdecodingofsinglecelldynamics
_version_	1725206958566277120

Techniques for Studying Decoding of Single Cell Dynamics

Similar Items