Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

Enhancer activity drives cell differentiation and cell fate determination, but it remains unclear how enhancers cooperate during these processes. Here we investigate enhancer cooperation during transdifferentiation of human leukemia B-cells to macrophages. Putative enhancers are established by bindi...

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Bibliographic Details
Main Authors: Jinmi Choi, Kseniia Lysakovskaia, Gregoire Stik, Carina Demel, Johannes Söding, Tian V Tian, Thomas Graf, Patrick Cramer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
transdifferentiation
transcriptional regulation
enhancer cooperation
c/ebpa
Online Access:https://elifesciences.org/articles/65381

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