Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder
Background: Major depressive disorder (MDD) is associated with a wide range of cognitive deficits. However, it remains unclear whether there will be a major cognitive deficit independently caused by depression at acute episodes of MDD.Method: A comprehensive neurocognitive test battery was used to a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00836/full |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jin Liu Jin Liu Qiangli Dong Qiangli Dong Xiaowen Lu Xiaowen Lu Jinrong Sun Jinrong Sun Liang Zhang Liang Zhang Mi Wang Mi Wang Ping Wan Hua Guo Futao Zhao Yumeng Ju Yumeng Ju Danfeng Yan Danfeng Yan Haolun Li Haolun Li Han Fang Han Fang Weilong Guo Weilong Guo Mei Liao Mei Liao Xiangyang Zhang Yan Zhang Yan Zhang Bangshan Liu Bangshan Liu Lingjiang Li Lingjiang Li |
| spellingShingle |
Jin Liu Jin Liu Qiangli Dong Qiangli Dong Xiaowen Lu Xiaowen Lu Jinrong Sun Jinrong Sun Liang Zhang Liang Zhang Mi Wang Mi Wang Ping Wan Hua Guo Futao Zhao Yumeng Ju Yumeng Ju Danfeng Yan Danfeng Yan Haolun Li Haolun Li Han Fang Han Fang Weilong Guo Weilong Guo Mei Liao Mei Liao Xiangyang Zhang Yan Zhang Yan Zhang Bangshan Liu Bangshan Liu Lingjiang Li Lingjiang Li Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder Frontiers in Psychiatry depression cognitive function neurocognition executive function processing speed |
| author_facet |
Jin Liu Jin Liu Qiangli Dong Qiangli Dong Xiaowen Lu Xiaowen Lu Jinrong Sun Jinrong Sun Liang Zhang Liang Zhang Mi Wang Mi Wang Ping Wan Hua Guo Futao Zhao Yumeng Ju Yumeng Ju Danfeng Yan Danfeng Yan Haolun Li Haolun Li Han Fang Han Fang Weilong Guo Weilong Guo Mei Liao Mei Liao Xiangyang Zhang Yan Zhang Yan Zhang Bangshan Liu Bangshan Liu Lingjiang Li Lingjiang Li |
| author_sort |
Jin Liu |
| title |
Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder |
| title_short |
Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder |
| title_full |
Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder |
| title_fullStr |
Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder |
| title_full_unstemmed |
Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder |
| title_sort |
exploration of major cognitive deficits in medication-free patients with major depressive disorder |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Psychiatry |
| issn |
1664-0640 |
| publishDate |
2019-11-01 |
| description |
Background: Major depressive disorder (MDD) is associated with a wide range of cognitive deficits. However, it remains unclear whether there will be a major cognitive deficit independently caused by depression at acute episodes of MDD.Method: A comprehensive neurocognitive test battery was used to assess the executive function, processing speed, attention, and memory in 162 MDD patients and 142 healthy controls (HCs). A multivariate analysis of variance, hierarchical regression analyses and general linear regression analyses were used to explore the possible major cognitive deficits and their predictor variables.Results: MDD patients showed extensive impairment in all four cognitive domains. Impairment of executive function and processing speed were found to persist even with other cognitive domains and clinical variables being accounted for. Executive function and processing speed were further predicted by total disease duration and depression severity, respectively.Conclusions: Executive function and processing speed may be two distinct major deficits at acute episodes of MDD. Furthermore, the executive function is likely originated from the cumulative effect of disease duration and processing speed is possibly derived from the temporary effect of current depressive episode. |
| topic |
depression cognitive function neurocognition executive function processing speed |
| url |
https://www.frontiersin.org/article/10.3389/fpsyt.2019.00836/full |
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doaj-2df9f2fe5bc34d1d8d30c5bbec68501d2020-11-25T01:15:00ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-11-011010.3389/fpsyt.2019.00836495280Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive DisorderJin Liu0Jin Liu1Qiangli Dong2Qiangli Dong3Xiaowen Lu4Xiaowen Lu5Jinrong Sun6Jinrong Sun7Liang Zhang8Liang Zhang9Mi Wang10Mi Wang11Ping Wan12Hua Guo13Futao Zhao14Yumeng Ju15Yumeng Ju16Danfeng Yan17Danfeng Yan18Haolun Li19Haolun Li20Han Fang21Han Fang22Weilong Guo23Weilong Guo24Mei Liao25Mei Liao26Xiangyang Zhang27Yan Zhang28Yan Zhang29Bangshan Liu30Bangshan Liu31Lingjiang Li32Lingjiang Li33Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, Zhumadian Psychiatric Hospital, Zhumadian, ChinaDepartment of Psychiatry, Zhumadian Psychiatric Hospital, Zhumadian, ChinaDepartment of Psychiatry, Zhumadian Psychiatric Hospital, Zhumadian, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaCAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaMental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaBackground: Major depressive disorder (MDD) is associated with a wide range of cognitive deficits. However, it remains unclear whether there will be a major cognitive deficit independently caused by depression at acute episodes of MDD.Method: A comprehensive neurocognitive test battery was used to assess the executive function, processing speed, attention, and memory in 162 MDD patients and 142 healthy controls (HCs). A multivariate analysis of variance, hierarchical regression analyses and general linear regression analyses were used to explore the possible major cognitive deficits and their predictor variables.Results: MDD patients showed extensive impairment in all four cognitive domains. Impairment of executive function and processing speed were found to persist even with other cognitive domains and clinical variables being accounted for. Executive function and processing speed were further predicted by total disease duration and depression severity, respectively.Conclusions: Executive function and processing speed may be two distinct major deficits at acute episodes of MDD. Furthermore, the executive function is likely originated from the cumulative effect of disease duration and processing speed is possibly derived from the temporary effect of current depressive episode.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00836/fulldepressioncognitive functionneurocognitionexecutive functionprocessing speed |