A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

Epidermal homeostasis depends on a balance between stem cell renewal and terminal differentiation. The transition between the two cell states, termed commitment, is poorly understood. Here, we characterise commitment by integrating transcriptomic and proteomic data from disaggregated primary human k...

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Bibliographic Details
Main Authors: Ajay Mishra, Bénédicte Oulès, Angela Oliveira Pisco, Tony Ly, Kifayathullah Liakath-Ali, Gernot Walko, Priyalakshmi Viswanathan, Matthieu Tihy, Jagdeesh Nijjher, Sara-Jane Dunn, Angus I Lamond, Fiona M Watt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
epidermis
commitment
stem cells
differentiation
protein dephosphorylation
Boolean networks
Online Access:https://elifesciences.org/articles/27356

Internet

https://elifesciences.org/articles/27356

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