Antibacterial Effect of (2E,2E)-4,4-Trisulfanediylbis(but-2-enoic acid) against Staphylococcus aureus.

Antibacterial Effect of (2E,2E)-4,4-Trisulfanediylbis(but-2-enoic acid) against Staphylococcus aureus.

A new highly active molecule, (2E, 2E)-4,4-trisulfanediylbis(but-2-enoic acid) (TSDB), was designed and synthesized through comparative molecular field analysis with the diallyl trisulfide structure of garlic. TSDB exerted a strong inhibitory effect against Staphylococcus aureus, with minimal inhibi...

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Main Authors: Tao Wu, Yina Huang, Yijun Chen, Min Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5967733?pdf=render
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spelling doaj-2df0244ceded442698138fb7da4002ea2020-11-24T21:54:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01135e019734810.1371/journal.pone.0197348Antibacterial Effect of (2E,2E)-4,4-Trisulfanediylbis(but-2-enoic acid) against Staphylococcus aureus.Tao WuYina HuangYijun ChenMin ZhangA new highly active molecule, (2E, 2E)-4,4-trisulfanediylbis(but-2-enoic acid) (TSDB), was designed and synthesized through comparative molecular field analysis with the diallyl trisulfide structure of garlic. TSDB exerted a strong inhibitory effect against Staphylococcus aureus, with minimal inhibitory and minimal bactericidal concentrations of 16 and 128 μg/mL, respectively. TSDB destructed the integrity of the S. aureus cell membrane but weakly damaged the bacterial cell wall. TSDB also increased the conductivity and protein expression in microbial broth but minimally influenced the level of extracellular alkaline phosphatase. TSDB could be a novel food preservative.http://europepmc.org/articles/PMC5967733?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Tao Wu
Yina Huang
Yijun Chen
Min Zhang
spellingShingle Tao Wu
Yina Huang
Yijun Chen
Min Zhang
Antibacterial Effect of (2E,2E)-4,4-Trisulfanediylbis(but-2-enoic acid) against Staphylococcus aureus.
PLoS ONE
author_facet Tao Wu
Yina Huang
Yijun Chen
Min Zhang
author_sort Tao Wu
title Antibacterial Effect of (2E,2E)-4,4-Trisulfanediylbis(but-2-enoic acid) against Staphylococcus aureus.
title_short Antibacterial Effect of (2E,2E)-4,4-Trisulfanediylbis(but-2-enoic acid) against Staphylococcus aureus.
title_full Antibacterial Effect of (2E,2E)-4,4-Trisulfanediylbis(but-2-enoic acid) against Staphylococcus aureus.
title_fullStr Antibacterial Effect of (2E,2E)-4,4-Trisulfanediylbis(but-2-enoic acid) against Staphylococcus aureus.
title_full_unstemmed Antibacterial Effect of (2E,2E)-4,4-Trisulfanediylbis(but-2-enoic acid) against Staphylococcus aureus.
title_sort antibacterial effect of (2e,2e)-4,4-trisulfanediylbis(but-2-enoic acid) against staphylococcus aureus.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2018-01-01
description A new highly active molecule, (2E, 2E)-4,4-trisulfanediylbis(but-2-enoic acid) (TSDB), was designed and synthesized through comparative molecular field analysis with the diallyl trisulfide structure of garlic. TSDB exerted a strong inhibitory effect against Staphylococcus aureus, with minimal inhibitory and minimal bactericidal concentrations of 16 and 128 μg/mL, respectively. TSDB destructed the integrity of the S. aureus cell membrane but weakly damaged the bacterial cell wall. TSDB also increased the conductivity and protein expression in microbial broth but minimally influenced the level of extracellular alkaline phosphatase. TSDB could be a novel food preservative.
url http://europepmc.org/articles/PMC5967733?pdf=render
work_keys_str_mv AT taowu antibacterialeffectof2e2e44trisulfanediylbisbut2enoicacidagainststaphylococcusaureus
AT yinahuang antibacterialeffectof2e2e44trisulfanediylbisbut2enoicacidagainststaphylococcusaureus
AT yijunchen antibacterialeffectof2e2e44trisulfanediylbisbut2enoicacidagainststaphylococcusaureus
AT minzhang antibacterialeffectof2e2e44trisulfanediylbisbut2enoicacidagainststaphylococcusaureus
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