Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2

Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2

Pituitary POMC secreting cells achieve high hormone expression levels after birth but the mechanism for this regulation is unclear. Here, the authors show that this process is driven cell autonomously by the differentiation factor Tpit that activates the bZIP transcription factors Creb3l2 and XBP1 t...

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Main Authors: Konstantin Khetchoumian, Aurélio Balsalobre, Alexandre Mayran, Helen Christian, Valérie Chénard, Julie St-Pierre, Jacques Drouin
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11894-3
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spelling doaj-2ded1151fab64ba68a4d5db6a8ce4a722021-05-11T11:26:29ZengNature Publishing GroupNature Communications2041-17232019-09-0110111310.1038/s41467-019-11894-3Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2Konstantin Khetchoumian0Aurélio Balsalobre1Alexandre Mayran2Helen Christian3Valérie Chénard4Julie St-Pierre5Jacques Drouin6Laboratoire de génétique moléculaire, Institut de recherches cliniques de Montréal (IRCM)Laboratoire de génétique moléculaire, Institut de recherches cliniques de Montréal (IRCM)Laboratoire de génétique moléculaire, Institut de recherches cliniques de Montréal (IRCM)Departments of Physiology, Anatomy and Genetics, University of OxfordDepartment of Biochemistry, McGill University, Rosalind and Morris Goodman Research CentreDepartment of Biochemistry, McGill University, Rosalind and Morris Goodman Research CentreLaboratoire de génétique moléculaire, Institut de recherches cliniques de Montréal (IRCM)Pituitary POMC secreting cells achieve high hormone expression levels after birth but the mechanism for this regulation is unclear. Here, the authors show that this process is driven cell autonomously by the differentiation factor Tpit that activates the bZIP transcription factors Creb3l2 and XBP1 to enhance translation and secretory capacities.https://doi.org/10.1038/s41467-019-11894-3
collection DOAJ
language English
format Article
sources DOAJ
author Konstantin Khetchoumian
Aurélio Balsalobre
Alexandre Mayran
Helen Christian
Valérie Chénard
Julie St-Pierre
Jacques Drouin
spellingShingle Konstantin Khetchoumian
Aurélio Balsalobre
Alexandre Mayran
Helen Christian
Valérie Chénard
Julie St-Pierre
Jacques Drouin
Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
Nature Communications
author_facet Konstantin Khetchoumian
Aurélio Balsalobre
Alexandre Mayran
Helen Christian
Valérie Chénard
Julie St-Pierre
Jacques Drouin
author_sort Konstantin Khetchoumian
title Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
title_short Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
title_full Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
title_fullStr Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
title_full_unstemmed Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
title_sort pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor creb3l2
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description Pituitary POMC secreting cells achieve high hormone expression levels after birth but the mechanism for this regulation is unclear. Here, the authors show that this process is driven cell autonomously by the differentiation factor Tpit that activates the bZIP transcription factors Creb3l2 and XBP1 to enhance translation and secretory capacities.
url https://doi.org/10.1038/s41467-019-11894-3
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AT aureliobalsalobre pituitarycelltranslationandsecretorycapacitiesareenhancedcellautonomouslybythetranscriptionfactorcreb3l2
AT alexandremayran pituitarycelltranslationandsecretorycapacitiesareenhancedcellautonomouslybythetranscriptionfactorcreb3l2
AT helenchristian pituitarycelltranslationandsecretorycapacitiesareenhancedcellautonomouslybythetranscriptionfactorcreb3l2
AT valeriechenard pituitarycelltranslationandsecretorycapacitiesareenhancedcellautonomouslybythetranscriptionfactorcreb3l2
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AT jacquesdrouin pituitarycelltranslationandsecretorycapacitiesareenhancedcellautonomouslybythetranscriptionfactorcreb3l2
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