Changes in Resurgent Sodium Current Contribute to the Hyperexcitability of Muscles in Patients with Paramyotonia Congenita

Changes in Resurgent Sodium Current Contribute to the Hyperexcitability of Muscles in Patients with Paramyotonia Congenita

Paramyotonia congenita (PMC) is a rare hereditary skeletal muscle disorder. The major symptom, muscle stiffness, is frequently induced by cold exposure and repetitive exercise. Mutations in human <i>SCN4A</i> gene, which encodes the α-subunit of Na<sub>v</sub>1.4 channel, are...

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Bibliographic Details
Main Authors: Chiung-Wei Huang, Hsing-Jung Lai, Pi-Chen Lin, Ming-Jen Lee
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biomedicines
Subjects:
paramyotonia congenita
Na<sub>v</sub>1.4 channel
resurgent currents
sustained currents
Online Access:https://www.mdpi.com/2227-9059/9/1/51

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