Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma

Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma

<p>Abstract</p> <p>A decrease in the incidence of human immune deficiency virus-associated Kaposi sarcoma (HIV-KS) and regression of some established HIV-KS lesions is evident after the introduction of highly active anti-retroviral treatment (HAART), and is attributed to generalize...

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Main Authors: Lemmer Johan, Feller Liviu
Format: Article
Language:English
Published: BMC 2008-01-01
Series:Infectious Agents and Cancer
Online Access:http://www.infectagentscancer.com/content/3/1/1
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spelling doaj-2dd2e79e803e4392845caa9e836dbcac2020-11-24T20:57:59ZengBMCInfectious Agents and Cancer1750-93782008-01-0131110.1186/1750-9378-3-1Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcomaLemmer JohanFeller Liviu<p>Abstract</p> <p>A decrease in the incidence of human immune deficiency virus-associated Kaposi sarcoma (HIV-KS) and regression of some established HIV-KS lesions is evident after the introduction of highly active anti-retroviral treatment (HAART), and is attributed to generalized immune restoration, to the reconstitution of human herpesvirus (HHV)-8 specific cellular immune responses, and to the decrease in HIV Tat protein and HHV-8 loads following HAART. However, a small subset of HIV-seropositive subjects with a low CD4+ T cell count at the time of introduction of HAART, may develop HIV-KS as immune reconstitution inflammatory syndrome (IRIS) within 8 weeks thereafter.</p> http://www.infectagentscancer.com/content/3/1/1
collection DOAJ
language English
format Article
sources DOAJ
author Lemmer Johan
Feller Liviu
spellingShingle Lemmer Johan
Feller Liviu
Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma
Infectious Agents and Cancer
author_facet Lemmer Johan
Feller Liviu
author_sort Lemmer Johan
title Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma
title_short Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma
title_full Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma
title_fullStr Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma
title_full_unstemmed Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma
title_sort insights into pathogenic events of hiv-associated kaposi sarcoma and immune reconstitution syndrome related kaposi sarcoma
publisher BMC
series Infectious Agents and Cancer
issn 1750-9378
publishDate 2008-01-01
description <p>Abstract</p> <p>A decrease in the incidence of human immune deficiency virus-associated Kaposi sarcoma (HIV-KS) and regression of some established HIV-KS lesions is evident after the introduction of highly active anti-retroviral treatment (HAART), and is attributed to generalized immune restoration, to the reconstitution of human herpesvirus (HHV)-8 specific cellular immune responses, and to the decrease in HIV Tat protein and HHV-8 loads following HAART. However, a small subset of HIV-seropositive subjects with a low CD4+ T cell count at the time of introduction of HAART, may develop HIV-KS as immune reconstitution inflammatory syndrome (IRIS) within 8 weeks thereafter.</p>
url http://www.infectagentscancer.com/content/3/1/1
work_keys_str_mv AT lemmerjohan insightsintopathogeniceventsofhivassociatedkaposisarcomaandimmunereconstitutionsyndromerelatedkaposisarcoma
AT fellerliviu insightsintopathogeniceventsofhivassociatedkaposisarcomaandimmunereconstitutionsyndromerelatedkaposisarcoma
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