Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

Pulmonary tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains a global pandemic, despite the widespread use of the parenteral live attenuated Bacillus Calmette–Guérin (BCG) vaccine during the past decades. Mucosal administration of next generation TB vaccines has great po...

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Bibliographic Details
Main Authors: Aneesh Thakur, Cristina Rodríguez-Rodríguez, Katayoun Saatchi, Fabrice Rose, Tullio Esposito, Zeynab Nosrati, Peter Andersen, Dennis Christensen, Urs O. Häfeli, Camilla Foged
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
H56/CAF01 vaccine
SPECT/CT imaging
dual-isotope 111In/67Ga
pulmonary immunization
T cells
mucosal immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02825/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02825/full

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