Assessing the Effects of Cytoprotectants on Selective Neuronal Loss, Sensorimotor Deficit and Microglial Activation after Temporary Middle Cerebral Occlusion

Assessing the Effects of Cytoprotectants on Selective Neuronal Loss, Sensorimotor Deficit and Microglial Activation after Temporary Middle Cerebral Occlusion

Although early reperfusion after stroke salvages the still-viable ischemic tissue, peri-infarct selective neuronal loss (SNL) can cause sensorimotor deficits (SMD). We designed a longitudinal protocol to assess the effects of cytoprotectants on SMD, microglial activation (MA) and SNL, and specifical...

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Bibliographic Details
Main Authors: Julius V. Emmrich, Sohail Ejaz, David J. Williamson, Young T. Hong, Sergey Sitnikov, Tim D. Fryer, Franklin I. Aigbirhio, Heike Wulff, Jean-Claude Baron
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Brain Sciences
Subjects:
selective neuronal loss
microglial activation
pet
ischemic stroke
kca3.1
tram-34
reperfusion injury
Online Access:https://www.mdpi.com/2076-3425/9/10/287

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