Synonymous Mutations of Porcine Igf1r Extracellular Domain Affect Differentiation and Mineralization in MC3T3-E1 Cells

Synonymous Mutations of Porcine Igf1r Extracellular Domain Affect Differentiation and Mineralization in MC3T3-E1 Cells

Owing to the wide application of miniature pigs in biomedicine, the formation mechanism of its short stature must be elucidated. The insulin-like growth factor 1 receptor (IGF-1R), which receives signals through the extracellular domain (ECD) binding with ligands, is crucial in regulating cell growt...

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Bibliographic Details
Main Authors: Chunli Wang, Siyao Wang, Songcai Liu, Yunyun Cheng, Hongwei Geng, Rui Yang, Tianqi Feng, Guanhong Lu, Xiaotong Sun, Jie Song, Linlin Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
synonymous mutations
IGF-1R
cell differentiation
osteoblast mineralization
protein conformation
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00623/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00623/full

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