| Summary: | NR<sup>+</sup> is a highly effective vitamin B<sub>3</sub> type supplement due to its unique ability to replenish NAD<sup>+</sup> levels. While NR<sup>+</sup> chloride is already on the market as a nutritional supplement, its synthesis is challenging, expensive, and low yielding, making it cumbersome for large-scale industrial production. Here we report the novel crystalline NR<sup>+</sup> salts, <span style="font-variant: small-caps;">d</span>/<span style="font-variant: small-caps;">l</span>/<span style="font-variant: small-caps;">dl</span>-hydrogen tartrate and <span style="font-variant: small-caps;">d</span>/<span style="font-variant: small-caps;">l</span>/<span style="font-variant: small-caps;">dl</span>-hydrogen malate. Their high-yielding, one-pot manufacture does not require specific equipment and is suitable for multi-ton scale production. These new NR<sup>+</sup> salts seem ideal for nutritional applications due to their bio-equivalence compared to the approved NR<sup>+</sup> chloride. In addition, the crystal structures of all stereoisomers of NR<sup>+</sup> hydrogen tartrate and NR<sup>+</sup> hydrogen malate and a comparison to the known NR<sup>+</sup> halogenides are presented.
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