Role of the Blood-Brain Barrier in the Formation of Brain Metastases

Role of the Blood-Brain Barrier in the Formation of Brain Metastases

The majority of brain metastases originate from lung cancer, breast cancer and malignant melanoma. In order to reach the brain, parenchyma metastatic cells have to transmigrate through the endothelial cell layer of brain capillaries, which forms the morphological basis of the blood-brain barrier (BB...

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Bibliographic Details
Main Authors:	István A. Krizbai, János Haskó, Csilla Fazakas, Judit Molnár, Imola Wilhelm
Format:	Article
Language:	English
Published:	MDPI AG 2013-01-01
Series:	International Journal of Molecular Sciences
Subjects:	blood-brain barrier cerebral endothelial cell tight junction paracellular transmigration astrocyte central nervous system metastasis breast cancer lung cancer melanoma
Online Access:	http://www.mdpi.com/1422-0067/14/1/1383

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