A Novel Melt-Dispersion Technique for Simplistic Preparation of Chlorpromazine-Loaded Polycaprolactone Nanocapsules

A Novel Melt-Dispersion Technique for Simplistic Preparation of Chlorpromazine-Loaded Polycaprolactone Nanocapsules

The aim of this study was to design, synthesize and optimize chlorpromazine hydrochloride (CPZ)-loaded, poly-ε-caprolactone (PCL) based nanocapsules, intended for site specific delivery to the frontal lobe, using a novel melt-dispersion technique that is non-arduous, inexpensive and devoid of any h...

Full description

Bibliographic Details
Main Authors:	Thiresen Govender, Yahya E. Choonara, Pradeep Kumar, Lisa C. Du Toit, Girish Modi, Dinesh Naidoo, Viness Pillay
Format:	Article
Language:	English
Published:	MDPI AG 2015-06-01
Series:	Polymers
Subjects:	neurotherapy chlorpromazine hydrochloride poly-ε-caprolactone Polysorbate 80 melt-dispersion technique nanocapsules central composite design
Online Access:	http://www.mdpi.com/2073-4360/7/6/1145

Similar Items

Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(ε-caprolactone) Nanocapsules
by: Thallysson Carvalho Barbosa, et al.
Published: (2019-09-01)

Spectrophotometric Determination of Chlorpromazine Hydrochloride Using 4-Nitroanilline by Oxidative Coupling Reaction
by: Al-rashidy et al.
Published: (2019-03-01)

Effect of chlorpromazine (largactil) on Porteus maze performance
by: Quinn, Michael James
Published: (2012)

The effects of chlorpromazine on flicker fusion threshold with intersensory stimulation
by: Kruger, Stanley Irwin
Published: (2018)

THE EFFECT OF LITHIUM ON ACUTE TOXICITY OF CHLORPROMAZINE IN MICE
by: Dehpour, et al.
Published: (1996-06-01)

THE EFFECT OF LITHIUM ON ACUTE TOXICITY OF CHLORPROMAZINE IN MICE
by: Dehpour, et al.
Published: (1996-06-01)

Electron spin resonance study of the chlorpromazine cation
by: Tapping, Robert L.
Published: (2011)

Bioequivalence of HTX-019 (aprepitant IV) and fosaprepitant in healthy subjects: a Phase I, open-label, randomized, two-way crossover evaluation
by: Ottoboni T, et al.
Published: (2018-03-01)

PLGA Biodegradable Nanoparticles Containing Perphenazine or Chlorpromazine Hydrochloride: Effect of Formulation and Release
by: Mohammed Halayqa, et al.
Published: (2014-12-01)

Effect of chlorpromazine on intact and irradiated aliquot ctdsDNA samples
by: Ali M. Abbed, et al.
Published: (2007-04-01)

Scientific Opinion on the re‐evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives
by: EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)
Published: (2015-07-01)

An investigation of a possible site of action of chlorpromazine /
by: Raitt, Jacob Rothwacks
Published: (1961)

Spectroelectrochemical examination of the reactions of chlorpromazine cation radical /
by: Mayausky, John S.
Published: (1982)

Electrospun Composites of Polycaprolactone and Porous Silicon Nanoparticles for the Tunable Delivery of Small Therapeutic Molecules
by: Steven J. P. McInnes, et al.
Published: (2018-03-01)

The Effect of Chlorpromazine on Avoidance Learning in Rats
by: Fain, Thomas Carl
Published: (1968)

RESISTANT CYCLIC VOMITING SYNDROME SUCCESSFULLY RESPONDING TO CHLORPROMAZINE
by: Hasan H. Özdemir, et al.
Published: (2014-01-01)

Effect of Pluronic Introduction to Polycaprolactone Substrate on the Blend Hydrophilicity by Molecular Dynamic Simulation
by: Mohammad Masoud Mirhosseini, et al.
Published: (2016-07-01)

Effect of oral contraceptives on the transport of chlorpromazine across the CACO-2 intestinal epithelial cell line
by: Brown, D, et al.
Published: (2003)

The interaction of structural analogs of dopamine, chlorpromazine and sulpiride with striatal dopamine receptors /
by: Wallace, Raye Ann
Published: (1987)

The Effects of Chlorpromazine on Reproductive System and Function in Female Rats
by: Zahra Zamani, et al.
Published: (2015-10-01)

Chlorpromazine-induced status epilepticus: A case report
by: Momčilović-Kostadinović Dragana, et al.
Published: (2013-01-01)

Melt electrospinning of daunorubicin hydrochloride-loaded poly (ε-caprolactone) fibrous membrane for tumor therapy
by: He Lian, et al.
Published: (2017-06-01)

The effect of chlorpromazine and its 7,8-dihydroxy derivative on the isolated guinea pig superior cervical ganglion /
by: DeGuzman, Melinda Hernandez
Published: (1978)

Withdrawal effect of Chlorpromazine and Diazepam on chick blood (Plasma, Red Blood Cell) Acetyl cholinesterase activity
by: Luaay K. Yacoub
Published: (2007-01-01)

Effects of Tween 80 on growth and biofilm formation in laboratory media
by: Christina Krogsård Nielsen, et al.
Published: (2016-11-01)

Comparative studies on thin polycaprolactone-tricalcium phosphate composite scaffolds and its interaction with mesenchymal stem cells
by: Gopinathan Janarthanan, et al.
Published: (2019-01-01)

Quenching of the intrinsic fluorescence of bovine serum albumin by chlorpromazine and hemin
by: Silva D., et al.
Published: (2004-01-01)

THE COMPARATIVE EFFECTS OF MORPHINE AND CHLORPROMAZINE ON THE ACQUISITIONOF CONDITIONED AVOIDANCE RESPONSE
by: Ageel, A. M. (Abdulrahman M.), 1943-
Published: (1974)

The effects of stress on schizophrenic male patients under chlorpromazine treatment
by: Cassidy, Clifford Nelson
Published: (2018)

Effect of long term Treatment of Chlorpromazine and Diazepam on the activity of acetyl cholinesterase in the chicks’ blood
by: Luaay K. Yacoub
Published: (2007-03-01)

Comparing the Velocity of Haloperidol, Chlorpromazine, Trifluoperazine, and Promethazine in Sedating of Aggressive Patients
by: Sayed Ghafour Mousavi, et al.
Published: (2019-08-01)

Computational Survey on the Effect of Changes in Halogenated Compounds on the Structural Properties in Chlorpromazine
by: saeid karimi
Published: (2015-11-01)

Chlorpromazine induced cataract in a young patient with schizophrenia
by: Divakaran Anjith, et al.
Published: (2010-01-01)

Suspected systemic uptake of chlorpromazine after retrobulbar injection
by: Ryan Cosgrove, et al.
Published: (2020-09-01)

Light-Induced Reactions of Chlorpromazine in the Presence of a Heterogeneous Photocatalyst: Formation of a Long-Lasting Sulfoxide
by: Arsou Arimi, et al.
Published: (2019-07-01)

From micelle to microemulsion: an investigation of structural changes using molecular dynamics
by: Amir Amani, et al.
Published: (2015-03-01)

Priapisme induit par la chlorpromazine: A propos de deux cas
by: I. Marrag, et al.
Published: (2016-06-01)

Determination of residual monomers in poly(lactide-co-ε-caprolactone) using gas chromatography
by: Lidong Feng, et al.
Published: (2021-01-01)

Agmatine prevents acute chlorpromazine-induced neurotoxicity in rats
by: Dejanović Bratislav, et al.
Published: (2015-01-01)

A gelatin/collagen/polycaprolactone scaffold for skin regeneration
by: Lin-Gwei Wei, et al.
Published: (2019-02-01)