De novo adult acute myeloid leukemia with two new mutations in juxtatransmembrane domain of the FLT3 gene: a case report

De novo adult acute myeloid leukemia with two new mutations in juxtatransmembrane domain of the FLT3 gene: a case report

Abstract Background Approximately 30% of adult acute myeloid leukemia (AML) acquire within fms-like tyrosine kinase 3 gene (FLT3) internal tandem duplications (FLT3/ITDs) in their juxtamembrane domain (JMD). FLT3/ITDs range in size from three to hundreds of nucleotides, and confer an adverse prognos...

Full description

Bibliographic Details
Main Authors:	Ismael F. Alarbeed, Abdulsamad Wafa, Faten Moassass, Bassel Al-Halabi, Walid Al-Achkar, Thomas Liehr, Imad Aboukhamis
Format:	Article
Language:	English
Published:	BMC 2021-01-01
Series:	Journal of Medical Case Reports
Subjects:	Acute myeloid leukemia FLT3-ITDs ITDs size Sanger sequencing Prognostic factors
Online Access:	https://doi.org/10.1186/s13256-020-02587-3

Similar Items

FLT3 Gene Mutation in Acute Myeloid Leukemia: Correlation with Hematological, Immunophenotypic, and Cytogenetic Characteristics
by: Sunitha Shankaralingappa, et al.
Published: (2021-06-01)

Molecular Diagnosis of FLT3 Mutations in Acute Myeloid Leukemia Patients
by: EK Zaikova, et al.
Published: (2019-03-01)

FLT3-ITD Mutation and FLT3 Ligand Plasma Level Were Not Associated with One-Year Survival of Indonesian Acute Myeloid Leukemia Patients
by: Rinaldi I, et al.
Published: (2021-02-01)

FLT3 and NPM1 gene mutations in patients with acute myeloid leukemias and the impact of FLT3-ITD mutations on the survival of patients with a normal karyotype
by: Irina Stepanovna Martynkevich, et al.
Published: (2010-12-01)

Targeted therapy for medullary and extramedullary relapse of FLT3-ITD acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation
by: Takahiro Kumode, et al.
Published: (2020-01-01)

Estudo do efeito da associação do ácido all-trans retinoico (ATRA) com inibidores do FLT3 em modelos de leucemia mieloide aguda com mutações internas em tandem no gene FLT3
by: Mendoza, Silvia Elena Sanchez
Published: (2019)

FLT3‐ITD mutations in acute myeloid leukaemia – molecular characteristics, distribution and numerical variation
by: Caroline Engen, et al.
Published: (2021-09-01)

Sex disparity in acute myeloid leukaemia with FLT3 internal tandem duplication mutations: implications for prognosis
by: Monica Hellesøy, et al.
Published: (2021-09-01)

Combined Expression of CD34 and FLT3-Internal Tandem Duplication Mutation Predicts Poor Response to Treatment in Acute Myeloid Leukemia
by: Abdellateif MS, et al.
Published: (2020-10-01)

Targeting FLT3 in acute myeloid leukemia using ligand-based chimeric antigen receptor-engineered T cells
by: Ying Wang, et al.
Published: (2018-05-01)

High fms-like tyrosine kinase-3 (FLT3) receptor surface expression predicts poor outcome in FLT3 internal tandem duplication (ITD) negative patients in adult acute myeloid leukaemia: A prospective pilot study from India
by: Surender Kumar Sharawat, et al.
Published: (2016-01-01)

Detection of FLT3 Oncogene Mutations in Acute Myeloid Leukemia Using Conformation Sensitive Gel Electrophoresis
by: Mamdooh Gari, et al.
Published: (2008-11-01)

FLT3 Mutation as a Significant Prognostic Marker in de novo Acute Myeloid Leukemia Patients: Incidence, Distribution and Association with Cytogenetic Findings in a Study from South India
by: Santhi Sarojam, et al.
Published: (2014-10-01)

Cytogenetics and FLT3-ITD mutation predict clinical outcomes in non transplant patients with acute myeloid leukemia
by: Pimjai Niparuck, et al.
Published: (2019-01-01)

Use of FLT3 inhibitors in acute myeloid leukemia remission induction or salvage therapy: systematic review and meta-analysis
by: Yang M, et al.
Published: (2018-08-01)

Long Noncoding RNA SOCS2-AS Promotes Leukemogenesis in FLT3-ITD+ Acute Myeloid Leukemia Through miRNA-221
by: Zhang R, et al.
Published: (2020-04-01)

The sensitivity of the FLT3-ITD detection method is an important consideration when diagnosing acute myeloid leukemia
by: Masahiro Sakaguchi, et al.
Published: (2020-01-01)

Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns
by: Wei Guan, et al.
Published: (2021-04-01)

FLT3 internal tandem duplication and FLT3-D835 mutation in 80 AML patients categorized into cytogenetic risk groups
by: Ewa Mały DEF, et al.
Published: (2010-10-01)

FLT3-ITD DNA allelic burden, but not mRNA levels, influences the biological characteristics of AML patients
by: Soare Dan S., et al.
Published: (2021-01-01)

ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia
by: Doh Yu Hwang, et al.
Published: (2020-05-01)

NPM1 and FLT3-(ITD) Gene mutations and laboratory findings in patients with acute myeloid leukemia in Northwest of Iran
by: Sanaat Z, et al.
Published: (2014-10-01)

Autophagie, une cible thérapeutique potentielle dans les leucémies aiguës myéloïdes exprimant FLT3-ITD
by: Heydt, Quentin
Published: (2017)

Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations—Possible Therapeutic Efficacy of Cabozantinib
by: Ya-Chen Ko, et al.
Published: (2019-03-01)

Evaluation of cytokines and soluble adhesion molecules in patients with newly diagnosed acute myeloid leukemia: the role of TNF-alpha and FLT3-ITD
by: Tomas Kupsa, et al.
Published: (2016-03-01)

High Expression of AHSP, EPB42, GYPC and HEMGN Predicts Favorable Prognosis in FLT3-ITD-Negative Acute Myeloid Leukemia
by: Gang-Zhi Zhu, et al.
Published: (2017-08-01)

Régulation et fonctions de CDC25A dans les leucémies aiguës myéloïdes avec mutation FLT3-ITD
by: Reutenauer Bertoli, Sarah
Published: (2015)

A dual inhibitor overcomes drug-resistant FLT3-ITD acute myeloid leukemia
by: Peihong Wang, et al.
Published: (2021-07-01)

Molecular Mechanisms of Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia: Ongoing Challenges and Future Treatments
by: Sebastian Scholl, et al.
Published: (2020-11-01)

FLT3 inhibitors: clinical potential in acute myeloid leukemia
by: Hospital MA, et al.
Published: (2017-02-01)

Régulation de l'expression protéique des récepteurs à activité tyrosine kinase FLT3 et KIT dans les leucémies aigües myéloïdes
by: Larrue, Clément
Published: (2015)

Autophagy activation mediates resistance to FLT3 inhibitors in acute myeloid leukemia with FLT3-ITD mutation
by: Chen, Y., et al.
Published: (2022)

Sorafenib - induced thyroiditis in patient with a relapse of acute myelomonocytic leukemia with FLT3-ITD mutation
by: Ya B Balzhanova, et al.
Published: (2019-08-01)

CXCR4 Inhibition Enhances Efficacy of FLT3 Inhibitors in FLT3-Mutated AML Augmented by Suppressed TGF-b Signaling
by: Bo-Reum Kim, et al.
Published: (2020-06-01)

Potential Effects of the FLT3-ITD Mutation on Chemotherapy Response and Prognosis of Acute Promyelocytic Leukemia
by: Song Y, et al.
Published: (2021-03-01)

Natural small molecule triptonide inhibits lethal acute myeloid leukemia with FLT3-ITD mutation by targeting Hedgehog/FLT3 signaling
by: Ying Xu, et al.
Published: (2021-01-01)

Clinical use of FLT3 inhibitors in acute myeloid leukemia
by: Sutamtewagul G, et al.
Published: (2018-10-01)

Molecular characterisation of NPM1 and FLT3-ITD mutations in a central South African adult de novo acute myeloid leukaemia cohort
by: Jean F. Kloppers, et al.
Published: (2021-06-01)

Discovery of 5-methyl-N-(2-arylquinazolin-7-yl)isoxazole-4-carboxamide analogues as highly selective FLT3 inhibitors
by: Daseul Im, et al.
Published: (2020-01-01)

<i>FLT3</i>-ITD Allelic Burden and Acute Promyelocytic Leukemia Risk Stratification
by: Andrew Y. Li, et al.
Published: (2021-03-01)