De novo adult acute myeloid leukemia with two new mutations in juxtatransmembrane domain of the FLT3 gene: a case report

De novo adult acute myeloid leukemia with two new mutations in juxtatransmembrane domain of the FLT3 gene: a case report

Abstract Background Approximately 30% of adult acute myeloid leukemia (AML) acquire within fms-like tyrosine kinase 3 gene (FLT3) internal tandem duplications (FLT3/ITDs) in their juxtamembrane domain (JMD). FLT3/ITDs range in size from three to hundreds of nucleotides, and confer an adverse prognos...

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Bibliographic Details
Main Authors: Ismael F. Alarbeed, Abdulsamad Wafa, Faten Moassass, Bassel Al-Halabi, Walid Al-Achkar, Thomas Liehr, Imad Aboukhamis
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Medical Case Reports
Subjects:
Acute myeloid leukemia
FLT3-ITDs
ITDs size
Sanger sequencing
Prognostic factors
Online Access:https://doi.org/10.1186/s13256-020-02587-3

Internet

https://doi.org/10.1186/s13256-020-02587-3

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