Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria

Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria

Garcia-Senosiain et al developed an in vitro opsonic phagocytosis (OP) assay using peripheral blood leukocytes that enabled quantification of the contribution of each phagocytic cell type in the OP of Plasmodium falciparum blood-stage merozoites, which have been associated with malaria protection. U...

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Main Authors: Asier Garcia-Senosiain, Ikhlaq Hussain Kana, Subhash Singh, Manoj Kumar Das, Morten Hanefeld Dziegiel, Sanne Hertegonne, Bright Adu, Michael Theisen
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02511-5
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spelling doaj-2da18a4ab8754c3db06f3fa3163abde92021-08-22T11:14:13ZengNature Publishing GroupCommunications Biology2399-36422021-08-014111010.1038/s42003-021-02511-5Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malariaAsier Garcia-Senosiain0Ikhlaq Hussain Kana1Subhash Singh2Manoj Kumar Das3Morten Hanefeld Dziegiel4Sanne Hertegonne5Bright Adu6Michael Theisen7Department for Congenital Disorders, Statens Serum InstitutDepartment for Congenital Disorders, Statens Serum InstitutIndian Institute of Integrative MedicineNational Institute of Malaria Research, Field UnitBlood Bank KI 2034, Department of Clinical Immunology, Copenhagen University HospitalCentre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital, RigshospitaletNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartment for Congenital Disorders, Statens Serum InstitutGarcia-Senosiain et al developed an in vitro opsonic phagocytosis (OP) assay using peripheral blood leukocytes that enabled quantification of the contribution of each phagocytic cell type in the OP of Plasmodium falciparum blood-stage merozoites, which have been associated with malaria protection. Using patient samples from Ghana and India, they demonstrate that peripheral blood neutrophils are the main phagocytes of P. falciparum blood-stage merozoiteshttps://doi.org/10.1038/s42003-021-02511-5
collection DOAJ
language English
format Article
sources DOAJ
author Asier Garcia-Senosiain
Ikhlaq Hussain Kana
Subhash Singh
Manoj Kumar Das
Morten Hanefeld Dziegiel
Sanne Hertegonne
Bright Adu
Michael Theisen
spellingShingle Asier Garcia-Senosiain
Ikhlaq Hussain Kana
Subhash Singh
Manoj Kumar Das
Morten Hanefeld Dziegiel
Sanne Hertegonne
Bright Adu
Michael Theisen
Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria
Communications Biology
author_facet Asier Garcia-Senosiain
Ikhlaq Hussain Kana
Subhash Singh
Manoj Kumar Das
Morten Hanefeld Dziegiel
Sanne Hertegonne
Bright Adu
Michael Theisen
author_sort Asier Garcia-Senosiain
title Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria
title_short Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria
title_full Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria
title_fullStr Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria
title_full_unstemmed Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria
title_sort neutrophils dominate in opsonic phagocytosis of p. falciparum blood-stage merozoites and protect against febrile malaria
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-08-01
description Garcia-Senosiain et al developed an in vitro opsonic phagocytosis (OP) assay using peripheral blood leukocytes that enabled quantification of the contribution of each phagocytic cell type in the OP of Plasmodium falciparum blood-stage merozoites, which have been associated with malaria protection. Using patient samples from Ghana and India, they demonstrate that peripheral blood neutrophils are the main phagocytes of P. falciparum blood-stage merozoites
url https://doi.org/10.1038/s42003-021-02511-5
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