Extracellular vesicle-encapsulated miR-22-3p from bone marrow mesenchymal stem cell promotes osteogenic differentiation via FTO inhibition

Extracellular vesicle-encapsulated miR-22-3p from bone marrow mesenchymal stem cell promotes osteogenic differentiation via FTO inhibition

Abstract Background Bone marrow mesenchymal stem cells (BMSCs) exhibit the capacity to self-renew and differentiate into multi-lineage cell types, including osteoblasts, which are crucial regulators of fracture healing. Thus, this study aims to investigate the effect of microRNA (miR)-22-3p from BMS...

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Bibliographic Details
Main Authors: Xueliang Zhang, Yongping Wang, Haiyan Zhao, Xingwen Han, Tong Zhao, Peng Qu, Guangjie Li, Wenji Wang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Stem Cell Research & Therapy
Subjects:
Bone marrow mesenchymal stem cells
Extracellular vesicles
miR-22-3p
FTO
MYC
Osteogenic differentiation
Online Access:http://link.springer.com/article/10.1186/s13287-020-01707-6

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http://link.springer.com/article/10.1186/s13287-020-01707-6

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