Design Strategy for the EPR Tumor-Targeting of 1,2-Bis(sulfonyl)-1-alkylhydrazines

Design Strategy for the EPR Tumor-Targeting of 1,2-Bis(sulfonyl)-1-alkylhydrazines

A design strategy for macromolecular prodrugs is described, that are expected to exhibit robust activity against most solid tumor types while resulting in minimal toxicities to normal tissues. This approach exploits the enhanced permeability, and retention (EPR) effect, and utilizes carefully engine...

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Bibliographic Details
Main Authors: Philip G. Penketh, Hugh S Williamson, Raymond P. Baumann, Krishnamurthy Shyam
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
anticancer drugs
targeting
EPR
activity confinement
sulfonylhydrazine
Evans blue
Online Access:https://www.mdpi.com/1420-3049/26/2/259

Internet

https://www.mdpi.com/1420-3049/26/2/259

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