<i>S</i>(+)-(2<i>E</i>)-<i>N</i>-(2-Hydroxypropyl)-3-Phenylprop-2-Enamide (KM-568): A Novel Cinnamamide Derivative with Anticonvulsant Activity in Animal Models of Seizures and Epilepsy

<i>S</i>(+)-(2<i>E</i>)-<i>N</i>-(2-Hydroxypropyl)-3-Phenylprop-2-Enamide (KM-568): A Novel Cinnamamide Derivative with Anticonvulsant Activity in Animal Models of Seizures and Epilepsy

Epilepsy is one of the most frequent neurological disorders affecting about 1% of the world’s human population. Despite availability of multiple treatment options including antiseizure drugs, it is estimated that about 30% of seizures still remain resistant to pharmacotherapy. Searching for new anti...

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Bibliographic Details
Main Authors: Agnieszka Gunia-Krzyżak, Ewa Żesławska, Karolina Słoczyńska, Dorota Żelaszczyk, Aleksandra Sowa, Paulina Koczurkiewicz-Adamczyk, Justyna Popiół, Wojciech Nitek, Elżbieta Pękala, Henryk Marona
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
anticonvulsant
antiseizure, cinnamamide derivatives
crystallography
drug development
epilepsy
preclinical safety evaluation
Online Access:https://www.mdpi.com/1422-0067/21/12/4372

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