Susceptibility of clinical isolates of Bacteroides fragilis group strains to cefoxitin, cefoperazone and ticarcillin/clavulanate

• Main Authors: PEIXOTO JÚNIOR Arnaldo Aires, ROCHA Márcia Maria de Negreiros P., MOREIRA José Luciano Bezerra, CARVALHO Cibele Barreto Mano de
• Format: Article
• Language: English
• Published: Universidade de São Paulo 2000-01-01
• Series: Revista do Instituto de Medicina Tropical de São Paulo
• Subjects: Bacteroides fragilis group; beta-lactam; Antimicrobial resistance; Anaerobic bacteria
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652000000300005
• ISSN: 0036-4665; 1678-9946

A total of 40 strains of the B. fragilis group was isolated from clinical specimens in two hospital centers in Fortaleza from 1993 to 1997. The most frequently isolated species was Bacteroides fragilis (19 strains) and most isolates came from intra-abdominal and wound infections. The susceptibility profile was traced for cefoxitin, cefoperazone and ticarcillin-clavulanate by using the agar dilution reference method. All isolates were susceptible to ticarcillin-clavulanate (128/2mug/ml). Resistance rates of 15 and 70% were detected to cefoxitin (64mug/ml) and cefoperazone (64mug/ml), respectively. Such regional results permit a better orientation in choosing this group of antibiotics for prophylaxis and therapy especially in relation to cefoxitin, which is frequently used in the hospital centers studied.